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    Silk Fibroin-Based Hybrid Nanostructured Coatings for Titanium Implantable Surfaces Modification

    Year: 2020

    Journal: Coatings, Volume 10, JUN

    Authors: Popescu, Simona; Zarif, Maria-Elena; Dumitriu, Cristina; Ungureanu, Camelia; Pirvu, Cristian

    Organizations: European Regional Development Fund through Competitiveness Operational Program [P_36_611, 107066]; Innovative Technologies for Materials Quality Assurance in Health, Energy and Environmental-Center for Innovative Manufacturing Solutions of Smart Biomaterials and Biomedical Surfaces - INOVABIOMED

    Keywords: titanium; TiO(2)nanotubes; silk fibroin; CeO(2)nanoparticles; antibacterial effect

    This study proposes the development of new architectures that combine nanostructured titanium surface and biodegradable polymers as a promising approach to achieve a better performance after bioactive agent incorporation. The silk fibroin protein that was extracted from silkwormBombyx moricocoons is important due to the remarkable characteristics, such as biocompatibility, good mechanical properties, adjustable degradation and drug stabilizing capabilities. The titanium substrate was firstly nanostructurated with TiO(2)nanotubes and then coated with silk fibroin using electrospinning and electrochemical deposition. The deposited silk film ability to become a bioactive implant coating with antibacterial properties after the encapsulation of the active agents such as CeO(2)was investigated. Important features of the new implant coating were analysed: surface properties, electrochemical stability in physiological simulated electrolytes, and antibacterial action againstEscherichia coli. The obtained results indicate that silk fibroin bioactive layers are a potential candidate for regenerative medicine.
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