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    Spherical nanoparticle-modified bacterial cellulose drives SH-SY5Y cell differentiation and inhibits bacterial proliferation

    Year: 2022

    Journal: Process Biochem., Volume 122, NOV, page 307–315

    Authors: Yu, Yatong; Shen, Hangyu; Wang, Xiaoying; Gibril, Magdi E.; Kong, Fangong; Wang, Shoujuan

    Organizations: Natural Science Foundation of Shandong Province [ZR2020MC156]; National Natural Science Foundation of China [31971605]; Foundation of State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Science [ZZ20210119]

    Keywords: Bacterial cellulose; Amination; Tissue engineering

    Bacterial cellulose (BC) possesses good physical and mechanical properties for tissue engineering, but its negatively charged surface hinders cell adhesion. Here, the surface charge of BC was modulated with 2 bromoethylamine hydrobromide (2 BrEA) via a one-step synthesis method performed in alkaline aqueous solutions at room temperature. Positively charged spherical nanoparticles were thus formed in situ on BC. The amination degree of ethylamine-modified BC materials (BC EAs) reached 2.80 mmol/g; whereas the crystallinity, fiber diameter, and water contact angle were 55.5-65.5%, 30-45 nm, and 32.5-44.9 degrees, respectively. BC-EAs possess good antibacterial effectiveness against Escherichia coli and Staphylococcus aureus. The CCK-8 and live/dead assays suggest that BC modified with 0.09 g/mL 2 - BrEA (BC-EA3) is biocompatible and possesses a high efficiency for promoting human neuroblastoma SH-SY5Y cell proliferation and differentiation. Its antibacterial ability is beneficial for preventing the formation of biofilms in the extracellular matrix during tissue and organoid formation, while the properties promoting SH-SY5Y cell proliferation and differentiation make BC-EA3 a good candidate for nerve- or other tissue engineering.
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