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    Surface-generated copper ions induce multilayer growth of small peptides

    Year: 2020

    Journal: Appl. Surf. Sci., Volume 507, MAR 30

    Authors: Landoulsi, Jessem; Dupres, Vincent; Methivier, Christophe; Mfiban, Ivan Leteyi; Cornette, Pauline; Colaco, Elodie; Pradier, Claire-Marie

    Keywords: Oligopeptide; Adsorption; XPS; AFM; Hybrid layer

    Herein, we investigate the adsorption behavior of a small peptide, Glu-Cys-Gly, in aqueous solution onto copper surface and unravel a mechanism of growth of a hybrid peptide-copper multilayer the thickness of which may exceed a hundred of nanometers. Thanks to a combined set of surface characterizations supported by theoretical considerations, we provide a comprehensive understanding of the driving force and parameters influencing multilayer growth. (i) The generation of Cu+ ions due to the dissolution of copper surface, modulated by pH, results in the formation of cuprous-thiolate complex made of two peptide molecules anchoring one Cu+ cation. (ii) The stability of this hybrid multilayers is ensured by intermolecular interactions between peptide-copper entities mainly through a combination of electrostatic interaction and hydrogen bonds which stabilize the supramolecular edifice.
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