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    Sustainable chitosan-based electrical responsive scaffolds for tissue engineering applications

    Year: 2021

    Journal: Sustain. Mater. Technol., Volume 28, JUL

    Authors: Scalera, Francesca; Monteduro, Anna Grazia; Maruccio, Giuseppe; Blasi, Laura; Gervaso, Francesca; Mazzotta, Elisabetta; Malitesta, Cosimino; Piccirillo, Clara

    Organizations: Fondazione con il Sud [2015-0243]; Tecnopolo per la medicina di precisione (TecnoMed Puglia) Regione Puglia [2117, CUP: B84I18000540002]; Tecnopolo di Nanotecnologia e Fotonica per la medicina di precisione (TECNOMED) FISR/MIURCNR [3449, CUP: B83B17000010001]

    Keywords: Conductive polymers; Chitosan; Tissue engineering; Graphitic carbon; Natural sources

    Electroconductive biomaterials have potential in the regeneration of electrically active biological tissues (neural, orthopaedic, cardiac). The aim of this study was to develop an electroconductive scaffold using natural and/or sustainable materials. A composite scaffold made of chitosan, a compound of natural origin, and with incorporated with graphitic carbon obtained from cork (natural and sustainable source) as an electroconductive filler, was prepared. Chitosan (Ch) scaffolds with different concentration of pyrolysed cork (PC) were prepared and fully characterised. An electroconductivity of 5.5 x 10(-5) S/cm, i.e. in the range of cardiac tissues, was obtained. FTIR and XPS analysis did not show the presence of chemical bonds between the two components. Despite this, the composite scaffold showed higher thermal stability; moreover, their mechanical strength was significantly higher than for the pure chitosan. The biocompatibility of Ch-PC composite scaffolds has been verified by SH-SY5Y neuroblastoma cell viability assay. This study shows that a sustainable composite made with chitosan and an innovative electroconductive filler has potential application in tissue engineering. (C) 2021 Elsevier B.V. All rights reserved.
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