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    The Effect of Ozone Treatment on the Physicochemical Properties and Biocompatibility of Electrospun Poly(epsilon)caprolactone Scaffolds

    Year: 2021

    Journal: Pharmaceutics, Volume 13, AUG

    Authors: Dabasinskaite, Lauryna; Krugly, Edvinas; Baniukaitiene, Odeta; Martuzevicius, Dainius; Ciuzas, Darius; Jankauskaite, Lina; Aukstikalne, Lauryna; Usas, Arvydas

    Organizations: European Regional Development Fund [01.2.2-LMT-K-718]

    Keywords: tissue engineering; electrospun scaffold; poly(epsilon)caprolactone; ozone treatment; hMDSC; IGF-1

    Ozonation has been proved as a viable surface modification technique providing certain properties to the scaffolds that are essential in tissue engineering. However, the ozone (O-3) treatment of PCL scaffolds in aqueous environments has not yet been presented. O-3 treatment performed in aqueous environments is more effective compared with traditional, executed in ambient air treatment due to more abundant production of hydroxyl radicals (center dot OH) within the O-3 reaction with water molecules. During interaction with center dot OH, the scaffold acquires functional groups which improve wettability properties and encapsulate growth factors. In this study, a poly(epsilon)caprolactone (PCL) scaffold was fabricated using solution electrospinning and was subsequently ozonated in a water reactor. The O-3 treatment resulted in the expected occurrence of oxygen-containing functional groups, which improved scaffold wettability by almost 27% and enhanced cell proliferation for up to 14 days. The PCL scaffold was able to withhold 120 min of O-3 treatment, maintaining fibrous morphology and mechanical properties.
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