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    The effect of protonation in a family of peptide based gemini amphiphiles on the interaction in Langmuir films

    Year: 2019

    Journal: J. Mol. Liq., Volume 284, 1-Jun, page 357–365

    Authors: Korchowiec, Beata; Gorczyca, Marcelina; Korchowiec, Jacek; Rubio-Magnieto, Jenifer; Lotfallah, Ahmed H.; Luis, Santiago V.; Rogalska, Ewa

    Organizations: project HPC Infrastructure for Grand Challenges of Science and Engineering

    Keywords: Gemini Amphiphilic Pseudopeptides (GAPs); Surface pressure; Molecular dynamics modeling; Polarization-modulation infrared reflection-absorption spectroscopy

    The behavior and properties of four new gemini amphiphilic pseudopeptides (GAPS) were studied in monomolecular films formed at the air-water interface using surface pressure measurements, polarization-modulation infrared reflection-absorption spectroscopy as well as computational modeling. The molecules used differed in the structure of the polar heads containing amino and amide groups and in the number of apolar hydrocarbon chains. To better understand the role of the polar heads in the intra- and intermolecular interaction, the experiments were performed at different pH values of the water subphase. The experimental and theoretical results show that the interaction between the molecules forming monolayers change in function of pH; these changes depend on the pseudopeptide used. We propose that the effects observed are due to the differences in the protonation state of the polar heads in the four molecules. This outcome may give a handle on preparation of pH-dependent supramolecular structures based on tailor-made GAPs. (C) 2019 Elsevier B.V. All rights reserved.
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