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    The role of carboxylic groups in heparin-mimicking polymer-functionalized surfaces for blood compatibility: Enhanced vascular cell selectivity

    Year: 2021

    Journal: Colloid Surf. B-Biointerfaces, Volume 201, MAY

    Authors: Zhang, Aiyang; Sun, Wei; Liang, Xinyi; Chen, Xianshuang; Li, Yuepeng; Liu, Xiaoli; Chen, Hong

    Organizations: National Natural Science Foundation of China [22075191, 21774089, 21935008]; National Key Research and Development Program of China [2016YFC1100402]; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

    Keywords: Heparin-mimicking polymer; Carboxylic groups; Vascular cell interactions; Surface modification; Blood compatibility

    Blood compatibility is an eternal topic of biomedical materials. The effect of heparin-mimicking polymers (HMPs) on blood compatibility has been well studied, especially the synergistic effect of sugar unit and sulfonate/sulfate unit. However, carboxylic groups also play an important role in HMPs. In this work, copolymers of sodium 4-vinyl-benzenesulfonate (SS) and 2-methacrylamido glucopyranose (MAG) (poly(SS-co-MAG)) and poly (acrylate acid) (PAA) were self-assembled on Au surfaces with different feed ratios. When self-assembly of poly (SS-co-MAG) alone, the optimized feed ratio of SS and MAG for vascular cell selectivity was 1:1 (PS1M1); at this ratio the Au-PS1M1 surface showed the highest human umbilical vein endothelial cells (HUVECs) density and the lowest human umbilical vein smooth muscle cells (HUVSMCs) density. When self-assembly of PAA alone (surface designated as Au-PAA), the proliferation of both HUVECs and HUVSMCs was inhibited. Compared with either PS1M1 or PAA alone, the surfaces modified with both PAA and PS1M1 at the feed ratio of 1:1 (material designated as Au-PSM/PAA-2) showed enhanced promoting effect on HUVECs as well as enhanced inhibiting effect on HUVSMCs, indicating stronger vascular cell selectivity of carboxylic groups in the presence of sugar and sulfonate units.
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