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    Titanium surface-grafted zwitterionic polymers with an anti-polyelectrolyte effect enhances osteogenesis

    Year: 2023

    Journal: Colloids and Surfaces B: Biointerfaces, Volume 226, 2023-06-01, page 113293

    Authors: Zhu, Bingbing; Jia, Erna; Zhang, Qimeng; Zhang, Yanyan; Zhou, Hua; Tan, Ying; Deng, Zhennan

    Keywords: Anti-polyelectrolyte effect; Osteogenesis; SI-ATRP; Titanium; Zwitterionic polymers

    Zwitterionic polymers have attracted considerable attention because of their anti-adsorption and unique anti-polyelectrolyte effects and was widely used in surface modification. In this study, zwitterionic copolymers (poly (sulfobetaine methacrylate-co-butyl acrylate) (pSB) coating on the surface of a hydroxylated titanium sheet using surface-initiated atom transfer radical polymerization (SI-ATRP) was successfully constructed. X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR) and Water contact angle (WCA) analysis proved the successful preparation of the coating. The swelling effect caused by the anti-polyelectrolyte effect was reflected in the simulation experiment in vitro, and this coating can promote the proliferation and osteogenesis of MC3T3-E1. Therefore, this study provides a new strategy for designing multifunctional biomaterials for implant surface modifications.
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