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    Vapor-phase glutaraldehyde crosslinked waste protein-based nanofiber nonwovens as an environmentally friendly wound dressing

    Year: 2022

    Journal: React. Funct. Polym., Volume 172, MAR

    Authors: Chen, Wenjie; Gao, Zishan; He, Ming; Dou, Yao; Yin, Guoqiang; Ding, Jiao

    Organizations: Key-Area Research and Development Program of Guangdong Province [2020B020224002]; Modern Agricultural Industrial Technology System of Guangdong Province [2020KJ118]; Research Projects of Chengdu Polytechnic [20KYTD07]; Guangdong Province Education Department Higher Education Young Creative Talents Project Special Funds [2018KQNCX116]; Characteristic Innovation Projects of Colleges and Universities in Guangdong Province [2020KTSCX173]; Graduate Science and Technology Innovation Fund [KJCX2021003]

    Keywords: Keratin; Gelatin; Nanofibre nonwoven; Electrospinning; Vapor-phase crosslinking

    Vapor-phase glutaraldehyde crosslinking was used to improve the performance of feather keratin/gelatin (FK/ Ge) nanofiber nonwovens for potential use as wound dressings. Crosslinking was performed by placing the electrospun nonwovens in a glutaraldehyde vapor for different times (1.5, 3, 4.5, 6, and 9 h). Fourier-transform infrared spectroscopy and X-ray diffraction analysis revealed strong interactions between FK and Ge, and verified the crosslinking of FK/Ge molecular chains by glutaraldehyde. Fibers in the crosslinked nonwovens formed a compact and porous structure that promotes cell proliferation and growth. Further, a proper extent of cross linking reaction can effectively improve the mechanical strength and water resistance of FK/Ge nanofiber nonwovens, while maintaining their water uptake and thermal degradation properties within an acceptable range. These improvements are attributed to the flexible control over the degree of vapor-phase crosslinking. In vitro tests demonstrated that the crosslinked samples not only lack cytotoxicity but also promote the rapid proliferation of human foreskin fibroblasts. These new crosslinked nanofiber nonwovens derived from waste materials are promising for wound repair and care.
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