Contact
    Start Publications Vitamin D3 Loaded Niosomes and Transfersomes Produced by ...
    ←  Publication Finder
    Attension

    Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control

    Year: 2020

    Journal: Foods, Volume 9, OCT

    Authors: Estupinan, Oscar R.; Garcia-Manrique, Pablo; del Carmen Blanco-Lopez, Maria; Matos, Maria; Gutierrez, Gemma

    Organizations: Consejeria de Educacion y Ciencia del Principado de Asturias [IDI/2018/000185]; Ministerio de Economia y Competitividad (MINECO, Spain) [MAT2017-84959-C2-1-R, BP-17-108]; Plan de Ciencia Tecnologia e Innovacion del Principado de Asturias/FEDER

    Keywords: niosomes; transfersomes; surface tension; ethanol injection method; encapsulation efficiency; vesicles stability

    Vesicular nanocarriers have an important role in drug delivery and dietary supplements. Size control and optimization of encapsulation efficiency (EE) should be optimized for those applications. In this work, we report on the identification of the crucial step (injection, evaporation, or sonication) innanovesicles (transfersomes and niosomes) preparation by theethanol injection method (EI). The identification of each production step on the final vesicle size was analyzed in order to optimize further scale-up process. Results indicated that the final size of transfersomeswas clearly influenced by the sonication step while the final size of niosomes was mainly governed by the injection step. Measurements of final surface tension of the different vesicular systems prepared indicate a linear positive tendency with the vesicle size formed. This relation could help to better understand the process and design a vesicular size prediction model for EI. Vitamin D3 (VitD3) was encapsulated in the systems formulated with encapsulation efficiencies larger than 90%. Interaction between the encapsulated compound and the membrane layer components is crucial for vesicle stability. This work has an impact on the scaling-up production of vesicles for further food science applications.
    View publication