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    Organic Electrochemical Transistors functionalized with Protein Minibinders for Sensitive and Specific Detection of SARS-CoV-2

    Year: 2023

    Authors: Huang, Po-Chun; Zhou, Ying; Porter, Erin B.; Saxena, Ravindra G.; Gomez, Andrea; Ykema, Matthew; Senehi, Naomi L.; Lee, Dongjoo; Tseng, Chia-Ping; Alvarez, Pedro J.; Tao, Yizhi J.; Li, Yilin; Verduzco, Rafael

    Keywords: SARS-CoV-2; biosensor; COVID-19; OECT; rapid detection

    There is a need for rapid, sensitive, specific, and low-cost virus sensors. Recent work has demonstrated that organic electrochemical transistors (OECTs) can detect the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Here, a simple and low-cost approach to the fabrication of OECT devices with excellent stability and unprecedented sensitivity and specificity for the detection of SARS-CoV-2 virus is demonstrated. The devices rely on the engineered protein minibinder LCB1, which binds strongly to SARS-CoV-2. The resulting devices exhibit excellent sensitivity for the detection of SARS-CoV-2 virus and SARS-CoV-2 spike protein receptor binding domain (RBD). These results demonstrate a simple, effective, and low-cost biomolecular sensor applicable to the real-time detection of SARS-CoV-2 virus and a general strategy for OECT device design that can be applied for the detection of other pathogenic viruses.
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