Screening for surface-induced instabilities in the development phase can help reduce the risk of late discovery of incompatibilities and mitigate potential challenges before they lead to program delays and unplanned costs. QSense QCM-D technology is used to analyze interactions of active pharmaceutical ingredients and excipients with materials used in manufacturing, storage, and administration.
Wettability plays an important role in many industrial applications where solid, and liquid interact. In the pharmaceutical industry, the solid is often in the form of a powder. In pharmaceutical powders, wettability plays a pivotal role in formulation, storage, and the performance of dosage forms.
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Adsorption of pharmaceutical molecules at the air-water interface can cause the net concentration of the drug in the solution to diminish during long storage time. This can lead to insufficient and inaccurate dosage for the patient. Surfactants are often used to inhibit the adsorption. To understand the problem better adsorption kinetics can be studied.
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