In the dynamic lifecycle of a biopharmaceutical drug, from inception to patient use, stability and material compatibility is crucial. The complex interactions with various surfaces during production, storage and administration can lead to challenges such as unexpected adsorption, concentration depletion, or the formation of proteinaceous particles.

Discover QSense® solution for biopharmaceutical drug development process

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Proactive screening to reduce risk

Detecting potential issues early is essential, as late discovery could disrupt timelines and result in financial setbacks. Proactive screening for surface-induced instabilities during development becomes vital to mitigate challenges and reduce the risk of late failure. QSense® QCM-D  helps you analyze biopharmaceutical interactions comprehensively. This method offers insights into surface interaction at the nanoscale, such as molecular adsorption, desorption, and structural rearrangements, facilitating rapid detection of potential incompatibilities. 

Key capabilities of QCM-D as an early assessment tool for Biopharmaceutical Success

Analyze Biopharmaceutical Interaction with Relevant Materials

Quickly assess the effect of materials used in manufacturing, storage, and administration on the full formulation early on in development.

Minimize Risk with Proactive Incompatibility Detection

Measure the adsorbed amount of the formulation candidate on relevant surface and identify ways to mitigate incompatibilities.

Real-time Monitoring of Antibody and Excipient Adsorption

Understand surfactant action mechanisms and potential as stabilizer in the relevant context.
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Assessment for formulation development
with QSense

  • Determine antibody adsorption levels on diverse surface materials
  • Gain insights into molecular arrangements at the surface
  • Identify surfaces susceptible to incompatibility issues
  • Evaluate the influence of excipients on antibody adsorption
  • Explore how variations in concentration, pH, temperature, surface material,
    or surfactant type impact adsorption levels.
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Read the case example

Download the white paper to learn more about how QSense analysis can be used to reduce the risk of late discovery of incompatibilities.

Download White Paper
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Measurement and phenomena

QSense is a surface-sensitive technology that detects molecule - surface interaction at the nanoscale. It can be used to analyze phenomena such as adsorption, desorption, and structural changes of surface adhering layers.

Adsorption

Adsorption

Desorption

Desorption

conformational change

Conformational change

Omni QSense 4th generation QCM-D platform

QSense is based on the QCM-D technology

Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) is a real-time, surface sensitive technique for analyzing surface-interaction phenomena, thin film formation and layer properties.

Discover QCM-D

QSense Benefits

Intuitive and automated lab bench instrument

Easy to implement in the lab

Time-resolved data on protein interactions

Full understanding of interaction processes and mechanisms

Down to 90μl required sample volume

Valuable results from small sample volumes

Results within hours

Fast indications of final outcome

Pre-programmable standard scripts

Easy to set and reproduce measurements

A wide range of sensors

Test interactions with various materials applied in pharmaceutical production, storage and administration

QSense Omni is the latest QSense instrument, giving you the sharpest QCM-D data and a smooth journey in the lab.

Discover QSense Omni

Explore QSense sensors

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QSense Sensors for Biopharma

QSense sensors enable you to measure interaction with several relevant surface materials used in production, storage and administration of antibodies and other biological drugs – from metals and glass material to polymers, for example stainless steel, borosilicate glass and bio-grade polymers.

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QSense PDMS Sensor

PDMS is an excellent choice for
lubrication of syringes and similar lab wares, where maintaining the integrity of stored fluids and biological samples is crucial. Additionally, its thermal and electrical insulation properties protect sensitive samples and components.

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Discover the Sensor for your needs

The sensor is at the heart of the QCM-D experiment. Browse the widest range of sensors on the market to find out which sensor material and coating is best suited for your research needs.

Publications

AstraZeneca

Screening of the binding affinity of serum proteins to lipid nanoparticles in a cell free environment

Johnson and Johnson

Quartz Crystal Microbalance as a Predictive Tool for Drug-Material of Construction Interactions in Intravenous Protein Drug Administration

Bristol-Myers Squibb

Particle Characterization for a Protein Drug Product Stored in Pre-Filled Syringes Using Micro-Flow Imaging, Archimedes, and Quartz Crystal Microbalance with Dissipation

Pfizer

Engineering a ceramic piston pump to minimize particle formation for a therapeutic immunoglobulin: A combined factorial and modeling approach

Novartis Pharma

Understanding the adsorption and potential tear film stability properties of recombinant human lubricin and bovine submaxillary mucins in an in vitro tear film model

Genentech

Viscoelastic characterization of high concentration antibody formulations using quartz crystal microbalance with dissipation monitoring