- Products
- QSense
- QCM-D Instruments
- QSense Omni
QCM-D
QSense Omni
QSense Omni gives you the sharpest QCM-D data and a smooth journey in the lab. Unfold unique insights into molecular interactions at surfaces and interfaces quicker, and base your decisions on reliable results from highly controlled measurements.
Phenomena
-
Adsorption
-
Desorption
-
Binding and interactions
-
Swelling
-
De-swelling, crosslinking and collapse
-
Degradation, corrosion and etching

Up to 4 automated measurement channels
Key features
-
Measure mass, thickness, and viscoelastic properties of rigid and soft films
7-harmonic QCM-D with unique QSense Decay technology enables qualitative and quantitative analysis -
Best limit of detection and sharpest QCM-D data
4 times lower noise level and better limit of detection than any other QCM-D instrument -
Automated quality controlled measurements
Save time and perform reproducible measurements with temperature controlled chamber -
Up to 4 individual measurement channels
Measure in parallel using same or different scripts, flow rates and temperatures -
The broadest offer of sensor surfaces and coatings
Set up model systems as close as possible to real-world conditions -
Develop and refine scripts with Live script editing
Adjust your scripts while running the experiment
Intuitive Software for Effortless Experimentation
As you set up your experiment, QSoft Omni software runs continuous quality controls in the background to guarantee ideal conditions for your measurement. While QSoft Omni gathers your data, Dfind simplifies your analysis process.
Label-free. Real-time. Multi-harmonic QCM-D.
Measurement conditions
-
Flow mode
-
Stagnant mode
-
Gas phase Requires add-on
-
Liquid phase
-
Harsh chemicals
-
Low temperature
-
High viscosity
-
Inert surface Requires add-on
-
High temperature Requires add-on
Why QSense Omni?
Resolve subtle mass & viscoelastic changes
Track adsorption, binding, swelling, and soft layer dynamics with multi-harmonic QCM-D.
- Real-time frequency & dissipation
- Characterize soft, hydrated layers
- Quantify kinetics and stability
Consistent results across runs & channels
Precision temperature control, clean fluidics, and robust sensors help deliver reproducible datasets.
- Stable baselines & controlled flow
- Independent parallel channels
- Quality checks before each run
Reduce hands-on time, boost throughput
Scripted sequences, sample queues, and smart monitoring streamline complex experiments.
- Guided setup & live monitoring
- Script once, reuse across projects
- Safe shutdown & audit logs
Adapt to your application
Choose flow rates, surfaces, and modules (e.g., electrochemistry) to match your study.
- Broad surface chemistries
- Optional method modules
- Open data export
Onboard guidance & intuitive software
From setup to analysis, the workflow supports new users while staying fast for experts.
- Templates for common assays
- Auto-save & annotations
- Shareable reports
Global application know-how
Choose flow rates, surfaces, and modules (e.g., electrochemistry) to match your study.
- Broad surface chemistries
- Optional method modules
- Open data export
What is QCM-D?
Quartz Crystal Microbalance with Dissipation (QCM-D) measures changes in frequency and energy dissipation of a vibrating quartz sensor. This enables simultaneous analysis of mass adsorption and viscoelastic properties of thin films at surfaces.
Unlike mass-only techniques, QCM-D provides insight into soft, hydrated, and complex layers — making it particularly valuable in biological, polymer, and industrial liquid systems.
Why it matters
-
Label-free measurement
-
Real-time kinetic data
-
Works in liquid environments
-
Characterizes soft & viscoelastic layers
Instrument Selector
Our Instrument Selector will guide you along the way to your new instrument. Answer a few questions and the tool will provide you with the top choices based on your specific needs.
Applications across science & industry
Protein, lipid & nanoparticle interactions
Characterize adsorption, binding strength, fouling, and layer stability for formulations, LNPs, and biologics.
Surface performance in physiological media
Assess coatings, biofouling resistance, and cleaning strategies under relevant flow and temperature.
EQCM-D for batteries & electrodes
Probe interphase formation and mass changes during cycling when coupled with electrochemistry modules.
Cleaning & deposition
Quantify soil removal, surfactant action, and deposition on relevant materials in real time.
Thin films & soft matter
Study swelling, crosslinking, and barrier properties in complex, hydrated systems.
Surface functionalization
Optimize chemistries and layer-by-layer assemblies with kinetic and viscoelastic readouts.
Engineering Innovations
Beyond core QCM-D performance, Omni introduces hardware innovations designed to improve reproducibility, speed, and user confidence in both industrial and academic environments.
Lorem ipsum
Thermal stability is critical in QCM-D measurements. Omni’s patented temperature regulation system ensures highly stable and uniform temperature conditions across the sensor chamber. This minimizes drift, improves baseline stability, and increases confidence in kinetic and long-duration experiments.
Why it matters: Better reproducibility, improved comparability between runs, and more reliable industrial validation data.
Direct Injection Technology
Omni’s direct injection capability enables rapid and controlled liquid exchange directly at the sensor surface. This reduces dispersion effects and improves temporal resolution during fast interaction studies.
Why it matters: Sharper kinetic transitions, more accurate association/dissociation analysis, and improved experimental repeatability.
Red Dot Award-Winning Design
QSense Omni has been recognized with the prestigious Red Dot Award for product design. The compact footprint, intuitive layout, and clean industrial aesthetics are engineered to enhance usability in modern laboratory environments.
Why it matters: Efficient lab integration, ergonomic workflow, and a system built for long-term reliability and daily use.
Correct & Repeatable Sensor Position
The new sensor mounting guide, along with automated system quality checks in the QSoft software, work together to ensure the sensor is mounted correctly for each measurement, and conditions are ideal for experiments to start. Using these new features in practice translates to 25-times less user-variability in the QCM-D data and improves thickness measurements of ex-situ coated films. The redesigned flow module automatically locks the sensor in place, and acts as a Faraday cage, leading to high-quality data with minimal drift.
Schematic of QSense Omni sensor alignment tool and sensor holder cassette.
(need highres image)
Low volume
The minimum sample volume for QSense Omni experiments is 90 microliters (µl), which is particularly beneficial in applications like pharmaceutical development when experiments involve expensive or limited-availability samples. A step-by-step guide for small-volume experiments is available to help execute these measurements efficiently and obtain optimal results.
(Add correct video+preview image)
Resources
Column heading
Nulla vitae elit libero, a pharetra augue. Donec sed odio dui. Cras justo odio, dapibus ac facilisis in, egestas eget quam. Morbi leo risus, porta ac consectetur ac, vestibulum at eros.
Trusted by research laboratories and industrial R&D teams worldwide.
-
Designed for Global Deployment
-
Direct sales & distributor network
-
Application specialist support
-
Training & onboarding programs
See QSense Omni in Your Application
Tell us about your surface analysis challenge. Our specialists will recommend a configuration tailored to your industry and workflow.
Fill in the form
Measurement range and capacity
| Measurement channels | 1 - 4 |
| Working temperature | 4 to 70 °C, up to 150 °C using add on chamber(QSense High Temperature chamber) |
| Sensors (frequency range) | 5 MHz (1-72) |
| Number of measured harmonics | 7, allows for full viscoelastic modeling |
Sample and fluidics
| Volume above sensor | ~ 20 μl |
| Minimum sample volume | ~ 90 μl |
| Flow rates | Typical flow rate 20 μl/min. Flow speed range 1-200 μl/min |
Performance characteristics
| Maximum time resolution | 300 data points per second (each data point represents an f and D value) |
| LOD (3 x noise) |
0.24 ng/cm2 See the graph below |
| Minimum noise | Frequency: 0.0045 Hz Mass: 0.08 ng/cm2 Dissipation: 1∙10-9 |
| Long-term stability* | Frequency: < 0.25 Hz/h Dissipation: < 0.04.10-6 /h Temperature: < 0.003˚C/h |
All specifications are subject to change without prior notice
* The temperature stability depends on variations in how the ambient affects the warming or cooling of the chamber. The specified temperature stability may not be reached if the room temperature changes more than ± 1° C, due to draft or heat source for example.
Values taken after 1 h measurement with a QSX 303 SiO sensor in DI water at 25° C, Flow 20 μl/min and a data rate of 1 datapoint/s. Data interval used for analysis: 2 min. Even better stability can be achieved by waiting longer than 1 hour. Weight excluding external power supply.
Optimal real-life performance
Applying a higher sample rate inevitably leads to higher noise and compromised limit of detection (LOD).
With significantly improved noise level, QSense Omni offers improved Limit of Detection. The figure and table below
describe the Limit of Detection of QSense Omni at three different sampling intervals, and demonstrates the low limit
of detection achieved also at high sample rates.
The below figure and table describe speed and limit of detection (LOD) per acquisition mode.

Speed and limit of detection (LOD) per acquisition mode. Theoretical limit of Detection (LOD) at different sample intervals. Limit of detection is set to 3 times frequency noise level.
Performance characteristics. Measurements were performed with QSX 303 SiO sensors at 20°C temperature, and in deionized water at flow of 15μL/min, using one measurement channel. Each measurement mode was measured for approximately 5 minutes, and standard deviation of data points was collected within a set time range of 1 min to statistically determine noise data.
Why QSense Omni
Resolve subtle mass & viscoelastic changes
Nulla vitae elit libero, a pharetra augue. Donec sed odio dui. Cras justo odio, dapibus ac facilisis in, egestas eget quam. Morbi leo risus, porta ac consectetur ac, vestibulum at eros.
Lorem ipsum
Nulla vitae elit libero, a pharetra augue. Donec sed odio dui. Cras justo odio, dapibus ac facilisis in, egestas eget quam. Morbi leo risus, porta ac consectetur ac, vestibulum at eros.
Lorem ipsum
Nulla vitae elit libero, a pharetra augue. Donec sed odio dui. Cras justo odio, dapibus ac facilisis in, egestas eget quam. Morbi leo risus, porta ac consectetur ac, vestibulum at eros.
CTA Banner
Body text lorem ipsum dolor sit amet, consectetur adipisicing elit.
QSoft and Dfind software
Discover QSoft Omni software - a new, user-friendly software designed to
guide you through experiment set-up and produce successful results. While you prepare your experiment the QSoft Omni software continuously makes quality controls in the background to ensure optimal conditions for your measurement. QSoft Omni is collecting your data whereas Dfind makes your analysis easier.
QSoft Omni features
- Guided workflow takes you
through experiment set-up - Automated quality checks in the
background helps ensure optimal
experiment outcome - Drag and drop interface and live
script editing makes it easy to
develop scripts - Event log featuring both
automated actions and user
annotation
Computer requirements
- USB 2.0 or higher with type A connector
- Intel Core i5 processor (or equivalent)
- 8 GB of RAM or better
- > 1920 x 1080 px screen resolutions
- Windows 10 or later
Add more possibilities
Have a look at a selection of available add-ons compatible with QSense Omni to expand your experimental set up and possibilities.
Electrochemistry Module
Want to conduct simultaneous QCM-D and electrochemistry measurements on the same surface? This module supports a wide range of electrochemical methods, for instance cyclic voltammetry and electrochemical impedance measurements to explore polymer behavior, electrostatic interactions, corrosion, etc.
Window Module
Giving optical access to the sensor surface, this module enables simultaneous QCM-D and microscopy measurements on the same surface. You can also perform light or irradiation sensitive measurements.
Open Module
The Open module is tubeless with the lowest possible sample volume requirement. You can directly pipette a minimal amount of liquid to cover the sensor. This module will provide for evaporation studies, external triggered reactions such as photo induced reaction and chemically triggered reactions.
High Temperature Chamber
With the High Temperature Chamber you can perform measurements in an extended temperature range of 4-150°C.
What our beta testers say
Peter Stengel, BASF SE
“I observed reduced cross-contamination, which is crucial for obtaining accurate data. I recognize the potential and value of this in our
future studies”
Franziska Tauber, BASF SE
“From my initial experience conducting the experiment, it became evident that it was designed with ease-of-use in mind, making it accessible to multiple users at the same time with no difficulties”
Learn more
We have gathered all our in-depth knowledge associated with Omni. Browse around amongst guides, overviews and white papers to find a topic of interest.
- QSense
How Excipients, Surfaces and Formulation Conditions Affect Therapeutic Proteins
- QSense
Basics of QCM-D
- QSense
How to Optimize the QCM-D Baseline Stability
- QSense
The Working Principles of QCM and QCM-D
- QSense
QCM-D in Drug Formulation and Storage
- QSense
QCM-D vs SPR
- QSense
QCM-D vs other QCMs
- QSense
What is Piezoelectricity?
- QSense
How QCM Results are Influenced by Layer Distribution
- QSense
Why the Resonance Frequency of a QCM Sensor is 5MHz
- QSense
Characterization of Polymer-based Systems
- QSense
Using QCM-D in the Food Industry
- QSense
What is Biocompatibility?
- QSense
Why it is Useful to use Multiple Overtones in QCM Measurements?
- QSense
Nanocellulose Research with QCM-D
- QSense
Analysis of Surfactant-Surface Interactions with QSense
- QSense
Getting Started with QSense Dfind
- QSense
Data Modeling in QSense Dfind
- QSense
QCM-D as a Screening Tool for Protein Adsorption
- QSense
Analyzing Vapor Uptake and Release with QCM-D
- QSense
Surface Science – a Field Rich in Science and Applications
- QSense
QCM-D Data Analysis
- QSense
QCM-D as a Tool to Study the Binding of Viruses
- QSense
Key Publications on the Formation of Supported Lipid Bilayers
- QSense
Characterization of Surfaces and Surface Reactions in Energy Storage
- QSense
Development of a New Method for the Formation of SLBs on Solid Support using QSense QCM-D
- QSense
QCM-D Technology: From Fundamental Membrane Biophysics to Translational Applications
- QSense
QSense Etching Guide
- QSense
QCM-D Characterization of Antimicrobial Lipid Interactions with Supported Lipid Bilayers: Towards Antiviral Applications in the Biomedical and Agricultural Sectors
- QSense
Monitoring of Polyelectrolyte Multilayer Build-up and Crosslinking using QCM-D
- QSense
Biomembrane Models and Interactions Therein
- QSense
Screening Nanoparticle - Protein Interactions
- QSense
The Sauerbrey Relation
- QSense
QSense Cleaning Profile
- QSense
QCM-D Studies of Engineered Nanoparticles
- QSense
Analytical Methods to Characterize Lipid-based Systems
- QSense
Characterization of Biomolecular Interactions
- QSense
QCM-D Analysis in Virus-related Research
- QSense
Determining Cleansing Efficacy of Elfan AT 84 using a QCM-D Assay
- QSense
Analyze Surface-induced Complement Activation
- QSense
Adsorption and Aggregation of Monoclonal Antibodies at Silicone Oil-Water Interfaces
- QSense
How do we Stop the Next Pandemic from an Unknown Virus?
- QSense
Characterization of Polymer Layer Swelling, Crosslinking and Collapse
- QSense
EQCM-D Analysis in Battery Development
- QSense
Analyzing Cleaning of Hard Surfaces with QSense
- QSense
QSense Analysis in CMP
- QSense
The Dissipation Factor in QCM-D Technology
- QSense
Temperature Stability in QCM Measurements
- QSense
What is Dissipation?
- QSense
What is a Viscoelastic material?
- QSense
How to Generate Quality QCM-D Data
- QSense
QCM-D vs other QCMs
- QSense
Assessing the inflammatory responses induced by biomaterials in contact with human blood using in vitro assays including QCM-D
- QSense
Implementing quartz crystal microbalance with dissipation monitoring for the development of novel biosensing assays
- QSense
QCM-D Publications in Battery Research
- QSense
How to read a QCM Specification
- QSense
Dfind Basic Training Course
- QSense
Information Obtained with QSense QCM-D
- QSense
How to Characterize Lipid-Based Systems with QCM-D
- QSense
QCM-D in Research
- QSense






