QCM-D

QSense Pro

Do you need to perform large-scale QCM-D analysis to study molecular interactions at surfaces and interfaces in real-time? The fully automated QSense Pro is best fit for the job.

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Guide

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Discover QSense Pro and all of its advantages in this 3 minutes long video.

phenomena

Adsorption
Desorption
Binding and interactions
Swelling
De-swelling, crosslinking and collapse
Degradation, corrosion and etching

Automated for large-scale analysis

Maximize your productivity

Improve reproducibility

Key features

Measure mass, thickness, and viscoelastic properties of rigid and soft films

7-harmonic QCM-D with QSense Decay technology enables qualitative and quantitative analysis
Handles small volumes

50 µl minimum required volume in flow mode
High throughput

Full automation and 8 measurement channels enables large-scale analysis
Automated liquid management

Allows for unattended measurements and saves time
Automated sample mixing

Improves reproducibility
Broadest offer of sensor surfaces and coatings

Set up model systems that are as close as possible to real-world conditions

Complete analysis set-up

QSOFT AND DFIND SOFTWARE

QSense software is tailored to help you maximize the potential of your QCM-D measurements. With QSoft capturing your data and Dfind simplifying your analysis, you can streamline your research process effortlessly.

measurement conditions

Flow mode
Stagnant mode
Liquid phase
Low temperature

A closer look

Let's dive into the specifications of QSense Pro. You can also compare the data to other QSense instruments to find what you are looking for.

Measurement range and capacity

Measurement channels	8
Working temperature	4 to 70 °C, 4 to 150 °C using accessory chamber (QSense High Temperature chamber)
Sensors (frequency range)	5 MHz (1-72)
Number of measured harmonics	7, allows for full viscoelastic modeling

Sample and fluidics

Minimum sample volume, stagnant mode	~ 20 μl ~ 1 μl minimum dispense volume
Minimum sample volume, flow mode	~ 50 μl
Flow rates	Typical flow rate 20 µl/min. Flow speed range 1-40 µl/min (4 sensors), 1-100 µl/min (1 sensor).

Performance characteristics

Maximum time resolution	100 data points per second (each data point represents an f and D value)
LOD (3 x noise)	1.08 ng/cm2
Sensitivity/limit of detection and noise	See the graph below
Minimum noise	Frequency: 0.02 Hz Mass: 0.4 ng/cm² Dissipation: 5∙10^-9
Long-term stability*	Frequency: < 1 Hz/h Dissipation: < 0.15∙10^-6 Temperature: < 0.02˚C/h

* The temperature stability depends on variations in how the ambient affects the warming or cooling of the chamber. The specified temperature stability may not be reached if the room temperature changes more than ± 1° C, if there is a draft or a heat source nearby. All specifications are subject to change without notice.

Optimal real-life performance

Applying a higher sample rate inevitably leads to higher noise and thus a compromised limit of detection (LOD). What aspect to prioritize depends on the studied surface interaction process. High time resolution may not be critical if very slow changes are studied, and a high measurement sensitivity may not be important if large changes are to be measured. With the 5 Speed-to-Noise modes you can select the right setting to maximize real-life performance for your measurement.

The below figure and table describe the real-measurement performance of QSense Pro for each acquisition mode using all channels. The sample interval can be significantly shortened (~4 times) by using a single channel.

Speed and limit of detection (LOD) per acquisition mode. Limit of detection is set to 1 S.D. of the baseline noise.

Performance characteristics. Measurements were performed with QSX 303 SiO₂ sensors at 20°C temperature, and in deionized water at a flow of 15 µL/min. Each measurement mode was measured for approximately 5 minutes.

Standard sensors

The sensor is at the heart of the QCM-D experiment. Browse the widest range of sensors on the market to find out which sensor material and coating is best suited for your research.

We offer over 50 standard sensors - from various metals, oxides and carbides to polymers, functionalized coatings and and standardized soils. Our sensors are developed and produced to provide you with stable, reliable and reproducible data. Full performance is ensured through extensive quality controls and guaranteed for one-time use according to the recommendations.

Customized sensors

Sensor materials and coatings based on your specific needs

Top suggestions

Stainless Steel SS2343

QSX 305

PS-Hydrophobic Polystyrene

See all sensors

QSoft and Dfind software

QSense softwares are designed for you to make the most out of your QCM-D measurements. QSoft is collecting your data whereas Dfind makes your analysis easier.

Dfind features

A complete analysis toolbox
One software for all your needs
Intuitive interface
Dfind supports you all the way through your analysis process - from data preparation to final reporting
Guided modelling
To take you through your analysis step by step
Material library
Configuring your modelling setup is easy, just select your sample material from the list
Autoplotting
Visualizes your results throughout the whole analysis
Smart tools
Dfind offers several analysis methods including shifts, rates and slopes to help you extract the information you need
Analyze all data in one go
To save your time, Dfind allows you to review, model and analyze multiple data sets in one go

Would you like to know more about the details of Dfind and learn how the subscription works?

Computer requirements

Required

PC with 64-bit Windows 7 SP1, 8, 8.1 or 10
At least 1366×768 px screen resolution
At least 4 GB RAM

Add more possibilities

Have a look at selected add-ons compatible with QSense Pro. Please note that adding a chamber will take away the opportunity to run parallell samples, on the other hand, it can widen your experimental setting.

Electrochemistry Module

For simultaneous QCM-D and electrochemistry measurements on the same surface. Enables cyclic voltammetry and electrochemical impedance measurements to explore polymer behavior, electrostatic interactions, corrosion, etc.

Ellipsometry Module

Enables simultaneous QCM-D and ellipsometry measurements on the same surface, which allows for quantification of solvent content in the film. It also gives a refined analysis of the morphological changes of the adsorbed film.

High Temperature Chamber

With the High Temperature Chamber you can perform measurements in an extended temperature range of 4-150°C.

Humidity Module

This module is designed to enable measurements of vapor uptake and release from thin films coated on the sensor.

Configure QSense Pro with accessories & modules in our Instrument Selector!

What our customers say

Our instruments are present at many prestigious universities and research facilities worldwide. Take a minute to find out what others say about QSense.

Prof. Nam-Joon Cho, School of Materials Science and Engineering, Nanyang Technological University, Singapore

"QCM-D technology is a key part of our biointerfacial science research that spans fundamental biomacromolecular investigations to applied studies involving antiviral drug development. The QSense instruments, which we have used for nearly two decades, are robust and can track complex biological phenomena in real-time and with label-free readouts that have helped us to deeply characterize a wide range of systems related to proteins and lipid membranes. Together with our analytical modeling efforts, there is a really bright future to continue applying QCM-D technology in new directions across many important scientific disciplines."

Nanyang Technological University, Singapore

Nanyang Technological University (NTU) is ranked one of the 15 top universities worldwide by QS World University Rankings. This research-intensive public university has over 33 000 undergraduate and postgraduate students and is home to world-class autonomous institutes.

Joshua A. Jackman, Assistant Professor, Sungkyunkwan University, South Korea

"Using QSense measurement tools, our lab has investigated many very interesting protein and lipid systems in aqueous and non-aqueous environments and the QCM-D measurement capabilities have proven critical to study molecular-level interaction behaviors at solid-liquid interfaces. One of the most exciting examples has involved antimicrobial lipids, in which case the QCM-D technique has proven extremely useful to distinguish the mechanisms of action of different compounds interacting with membrane-mimicking supported lipid bilayers. Such mechanistic distinctions were seen for the first time by the QCM-D technique, demonstrating its potential to complement and in some cases surpass the analytical capabilities of traditional biological assays. Looking forward, we see enormous potential to translate fundamental insights obtained from QCM-D measurements into numerous applications across the healthcare, biotechnology, and agricultural spaces among various opportunities."

Sungkyunkwan University, Korea

Founded already in 1398, Sungkyunkwan University has a rich history of producing high-end research scientists. Today, it is ranked number one among the private universities in Korea. Sungkyunkwan University takes great pride in its innovative spirit and puts resources into research and development.

Professor Dr. Marité Cárdenas, Health and Society, Malmö University

"QSense instruments are a great tool for our biophysical research. They enable rapid screening for biomolecular interaction at lipid bilayers and also allow optimizing the parameters for deposition of thin films. The instrument is easy to use, and has a long working life as long as you follow the maintenance instructions! The technical staff at Biolin Scientific are a pleasure to work with: They are nice and always give quick feedback and support."

Malmö University, Sweden

With its strong focus on innovative education and research, Malmö University was awarded as one of the top five highest quality education areas in Sweden back in 2007. Here, diversity makes all the difference. Malmö University has over 240 partner universities globally, and 1 out of 3 students come from an international background.

Learn more

We have gathered all our in-depth knowledge associated with QSense Pro. Browse around amongst guides, overviews and white papers to find a topic of interest.

QSense

Webinar

How Excipients, Surfaces and Formulation Conditions Affect Therapeutic Proteins

Can QCM-D quantify how surfactants affect protein-surface interaction? Watch this webinar with Dr. Archana Jaiswal to find out more.

Go there

QSense

Webinar

Basics of QCM-D

Learn the fundamentals of the technology, its possibilities and limitations and get a deeper understanding of nanometer layers.

Go there

QSense

Guide

How to Optimize the QCM-D Baseline Stability

9 steps to eliminate error sources and optimize reproducibility

Download

QSense

Overview

The Working Principles of QCM and QCM-D

Learn the fundamentals of how the technologies work, and what is the difference between them.

Biolin Scientific China

German Webshop

In a hurry?

phenomena

Key features

Measure mass, thickness, and viscoelastic properties of rigid and soft films

Handles small volumes

High throughput

Automated liquid management

Automated sample mixing

Broadest offer of sensor surfaces and coatings

measurement conditions

A closer look

Measurement range and capacity

Sample and fluidics

Performance characteristics

Optimal real-life performance

Top suggestions

See all sensors

QSoft and Dfind software

Dfind features

Computer requirements

Required

Recommended

Add more possibilities

Electrochemistry Module

Ellipsometry Module

High Temperature Chamber

Humidity Module

What our customers say

Prof. Nam-Joon Cho, School of Materials Science and Engineering, Nanyang Technological University, Singapore

Nanyang Technological University, Singapore

Joshua A. Jackman, Assistant Professor, Sungkyunkwan University, South Korea

Sungkyunkwan University, Korea

Professor Dr. Marité Cárdenas, Health and Society, Malmö University

Malmö University, Sweden

Learn more

How Excipients, Surfaces and Formulation Conditions Affect Therapeutic Proteins

Basics of QCM-D

How to Optimize the QCM-D Baseline Stability

The Working Principles of QCM and QCM-D

QCM-D in Drug Formulation and Storage

QCM-D vs SPR

QCM-D vs other QCMs

What is Piezoelectricity?

How QCM Results are Influenced by Layer Distribution

Why the Resonance Frequency of a QCM Sensor is 5MHz

Characterization of Polymer-based Systems

Using QCM-D in the Food Industry

What is Biocompatibility?

Why it is Useful to use Multiple Overtones in QCM Measurements?

Nanocellulose Research with QCM-D

Analysis of Surfactant-Surface Interactions with QSense

Getting Started with QSense Dfind

Data Modeling in QSense Dfind

QCM-D as a Screening Tool for Protein Adsorption

Analyzing Vapor Uptake and Release with QCM-D

Surface Science – a Field Rich in Science and Applications

QCM-D Data Analysis

QCM-D as a Tool to Study the Binding of Viruses

Key Publications on the Formation of Supported Lipid Bilayers

Characterization of Surfaces and Surface Reactions in Energy Storage

Development of a New Method for the Formation of SLBs on Solid Support using QSense QCM-D

QCM-D Technology: From Fundamental Membrane Biophysics to Translational Applications

QSense Etching Guide

QCM-D Characterization of Antimicrobial Lipid Interactions with Supported Lipid Bilayers: Towards Antiviral Applications in the Biomedical and Agricultural Sectors

Monitoring of Polyelectrolyte Multilayer Build-up and Crosslinking using QCM-D

Biomembrane Models and Interactions Therein

Screening Nanoparticle - Protein Interactions

The Sauerbrey Relation

QSense Cleaning Profile

QCM-D Studies of Engineered Nanoparticles

Analytical Methods to Characterize Lipid-based Systems

Characterization of Biomolecular Interactions

QCM-D Analysis in Virus-related Research

Determining Cleansing Efficacy of Elfan AT 84 using a QCM-D Assay

Analyze Surface-induced Complement Activation

Adsorption and Aggregation of Monoclonal Antibodies at Silicone Oil-Water Interfaces

How do we Stop the Next Pandemic from an Unknown Virus?

Characterization of Polymer Layer Swelling, Crosslinking and Collapse