Overview

Most suitable when

  • You need maximized throughput
    The 8-channel system can produce a lot of data every day
  • You want to test and compare samples
    8 channels and 4 separately controlled syringe pumps let you evaluate several samples and parameters in one go
  • You need highly reproducible results
    The fully automated system minimizes human errors and maximizes user-independence
  • You want to conduct experiments in both high and low temperatures
    The instrument works with a temperature range between 4-70 °C
  • You need more time
    The system can be pre-programmed and left unattended during experiments, leaving you with time to do other things

Widen your view

This 3-minute video will give you a quick view of QSense Pro measurements and applications. Watch the video in fullscreen for the best experience. 

3 reasons to invest

Increased productivity

The 8 channels of QSense Pro give you an opportunity to be fast and to produce lots of data every day. The fully automated system can be pre-programmed and left unattended during experiments, saving your time.

Compare several samples at the same time

Syringe pumps that run separately enable 4 channels to be used independently with different samples and measurement sequences. Hence, you can evaluate several parameters in parallel.

Highly reproducible results

Automated measurements decrease the risk of user dependency and give you more reproducible results. Also, high precision flow-control is ensured by syringe pumps. Programming of automated mixing, including gradients of samples, increases reproducibility.

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Specifications

A closer look

Let's dive into the specifications of QSense Pro. You can also compare the data to other QSense instruments to find what you are looking for. 

Compare QSense range

Measurement range and capacity

Measurement channels
Working temperature 4 to 70 °C, 4 to 150 °C using accessory chamber (QSense High Temperature chamber)
Sensors (frequency range) 5 MHz (1-72)
Number of measured harmonics 7, allows for full viscoelastic modeling


Sample and fluidics 

Minimum sample volume, stagnant mode ~ 15 μl
~ 1 μl minimum dispense volume
Minimum sample volume, flow mode ~ 50 μl
Flow rates Typical flow rate 20 µl/min. Flow speed range 1-40 µl/min (4 sensors), 1-100 µl/min (1 sensor).

Performance characteristics 

Maximum time resolution 100 datapoints per second (each datapoint represents an f and D value)
Sensitivity/limit of detection and noise See the graph below
Long-term stability* Frequency: < 1 Hz/h
Dissipation: < 0.15∙10-6
Temperature: < 0.02˚C/h

Software

  QSoft Acquisition software Dfind Analysis software
Measurement channels Time-resolved Frequency and Dissipation for 7 harmonics Thickness (or mass), viscosity, shear modulus and the frequency dependence of the viscosity and shear modulus. Kinetics, slope, rise time and more
Computer requirements USB 2.0 PC with 64-bit
> 1366×768 px screen resolution
> 4 GB RAM
Operating system Windows 10 or later (earlier Windows versions may not fully work and support cannot be guaranteed)
Import/export Excel, BMP, JPG, WMF, GIF, PCX, PNG, TXT CSV files. Decimal separator, full stop or comma

Electrical data

Power supply and frequency 100-120 / 220-240 V AC / 50/60 Hz
The power supply should be properly grounded

Dimensions and weight

  Height (cm) Width (cm) Depth (cm) Weight (kg)
Complete instrument 70 67 57 83

* The temperature stability depends on variations in how the ambient affects the warming or cooling of the chamber. The specified temperature stability may not be reached if the room temperature changes more than ± 1° C, if there is a draft or a heat source nearby. All specifications are subject to change without notice. 

Optimal real-life performance

Applying a higher sample rate inevitably leads to higher noise and thus a compromised limit of detection (LOD). What aspect to prioritize depends on the studied surface interaction process. High time resolution may not be critical if very slow changes are studied, and a high measurement sensitivity may not be important if large changes are to be measured. With the 5 Speed-to-Noise modes you can select the right setting to maximize real-life performance for your measurement.

The below figure and table describe the real-measurement performance of QSense Pro for each acquisition mode using all channels. The sample interval can be significantly shortened (~4 times) by using a single channel.

Pro LOD graf

Speed and limit of detection (LOD) per acquisition mode. Limit of detection is set to 1 S.D. of the baseline noise.


Performance characteristics. Measurements were performed with QSX 303 SiO2 sensors at 20°C temperature, and in deionized water at a flow of 15 µL/min. Each measurement mode was measured for approximately 5 minutes.

Sensors

Standard sensors
The sensor is at the heart of the QCM-D experiment. Browse the widest range of sensors on the market to find out which sensor material and coating is best suited for your research.
We offer over 50 standard sensors - from various metals, oxides and carbides to polymers, functionalized coatings and and standardized soils. Our sensors are developed and produced to provide you with stable, reliable and reproducible data. Full performance is ensured through extensive quality controls and guaranteed for one-time use according to the recommendations.
Customized sensors
Sensor materials and coatings based on your specific needs
Read more

See all sensors

Explore our sensors

Software

QSoft and Dfind software

QSense softwares are designed for you to make the most out of your QCM-D measurements. QSoft is collecting your data whereas Dfind makes your analysis easier. 

Dfind features

  • A complete analysis toolbox 
    One software for all your needs 
  • Intuitive interface 
    Dfind supports you all the way through your analysis process - from data preparation to final reporting
  • Guided modelling
    To take you through your analysis step by step 
  • Material library
    Configuring your modelling setup is easy, just select your sample material from the list
  • Autoplotting
    Visualizes your results throughout the whole analysis
  • Smart tools
    Dfind offers several analysis methods including shifts, rates and slopes to help you extract the information you need
  • Analyze all data in one go
    To save your time, Dfind allows you to review, model and analyze multiple data sets in one go
Would you like to know more about the details of Dfind and learn how the subscription works?

Learn more about Dfind!

Computer requirements

Required
  • PC with 64-bit Windows 7 SP1, 8, 8.1 or 10
  • At least 1366×768 px screen resolution
  • At least 4 GB RAM


Recommended
  • 1920×1080 Full HD screen resolution.
  • At least 8 GB RAM
  • At least 50 GB HD space
  • Core i5 5th generation Intel (or comparable) processor or better

Accessories

Add more possibilities

Have a look at selected add-ons compatible with QSense Pro. Please note that adding a chamber will take away the opportunity to run parallell samples, on the other hand, it can widen your experimental setting. 

Testimonials

What our customers say

Our instruments are present at many prestigious universities and research facilities worldwide. Take a minute to find out what others say about QSense. 

citat8

Marité Cárdenas on QSense

"QSense instruments are a great tool for our biophysical research. They enable rapid screening for biomolecular interaction at lipid bilayers and also allow optimising the parameters for deposition of thin films."

malmö universitet

Professor Dr. Marité Cárdenas, Health and Society, Malmö University

"The instrument is easy to use, and has a long working life as long as you follow the maintenance instructions! The technical staff at Biolin Scientific are a pleasure to work with: They are nice and always give quick feedback and support."

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Kenichi Sakai on QSense

"We regard QCM-D as a valuable measuring tool due to its high sensitivity and stability and find it applicable for versatile studies because of its availabilities of sensors with different types of surfaces. In this context I would say QCM-D is the best suitable solution for simulating a variety of nanoscale interaction behaviors both real-time & in-situ."

Jodie Lutkenhaus-1

Kenichi Sakai, Associate Professor, Tokyo University of Science

"We are working on academic research in the field of colloid and interface chemistry and our main work is synthesis of novel surfactants and characterization of their properties. We use QCM-D as a must-tool to comprehend molecular adsorption/desorption behaviors specifically observed at a solid-liquid interface."

citat8

Jodie Lutkenhaus on QSense

"We can monitor the mass change of our system in real-time. I can tell you that for every electron moved, this amount of mass changed. That’s powerful. You can’t really get that with any other system."

Jodie Lutkenhaus

Jodie Lutkenhaus, Associate Professor, Texas A&M University

"We use the QSense high temperature model that allows us to investigate polyelectrolyte complexes and their response to temperature. We’re also using the electrochemistry module so we can run our standard electrochemical measurements at the same time as we run the QCM-D."

citat8

Malkiat Johal on QSense

"I have found QSense to be one of the best techniques for an undergraduate lab because it’s turnkey and it requires very little maintenance."

Johal Malkiat-1

Malkiat Johal, Professor of Chemistry, Pomona College

"The operating principles are straightforward and the students can focus on the science. And so, that’s something that we have been really happy with, it really works in this kind of setting. It’s an ideal method for an undergraduate surface science lab."

Knowledge

Learn more

We have gathered all our in-depth knowledge associated with QSense Pro. Browse around amongst guides, overviews and white papers to find a topic of interest. 

  • QSense
Guide

How to read a QCM Specification

There are key parameters to keep an eye on when investing in a new QCM instrument. Learn what they mean, and why they are important.

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  • QSense
Overview

Information Obtained with QSense QCM-D

We have summarized the parameters and processes that can be studied with QCM-D for you.

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  • QSense
Overview

How to Characterize Lipid-Based Systems with QCM-D

You get a brief overview of how to analyze lipid layer formation dynamics, structure and layer quality.

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  • QSense
Guide

QSense Cleaning Profile

Explore a new way to evaluate product performance of detergents with our step-by-step guide.

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  • QSense
White Paper

QCM-D vs other QCMs

We sort out the the differences between QCM methods to answer the question - does it matter which one I use?

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  • QSense
Overview

The Sauerbrey Relation

Time to learn how the Sauerbrey relation is derived and what the parameters mean.

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  • QSense
Guide

QCM-D Data Analysis

We put together guidelines for you on how to evaluate which method to use, and what happens if you choose the wrong approach.

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  • QSense
Overview

QCM-D Studies of Engineered Nanoparticles

In this overview we explore three examples of nanoparticle analysis with QCM-D.

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  • QSense
Overview

Analytical Methods to Characterize Lipid-based Systems

In this overview, Prof. Nam-Joon Cho, Nanyang Technological University, Singapore, has compiled a list of the analytical methods he uses in his research to characterize lipid-based systems.

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  • QSense
Video

Development of a New Method for the Formation of SLBs on Solid Support using QSense QCM-D

Watch our interview with Prof. Nam-Joon Cho, Nanyang Technological University, about the SALB-project.

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  • QSense
Webinar

Determining Cleansing Efficacy of Elfan AT 84 using a QCM-D Assay

Hear Fredrik Andersson, Scientist at Global R&D, Nouryon, talk about how they used the QSense results to differentiate Elfan AT 84.

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  • QSense
Case Study

Analyzing Cleaning of Hard Surfaces with QSense

Learn how to assess cleaning efficiency using model and standardized stains.

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  • QSense
Guide

QSense Etching Guide

Learn how to use QSense technology for assessment of detergent etching properties.

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  • QSense
List

QCM-D in Research

Explore the work of Prof. Nam-Joon Cho and his research group through their publications.

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  • QSense
Overview

Key Publications on the Formation of Supported Lipid Bilayers

We gathered 8 research studies where QCM-D was used as a central analysis method.

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  • QSense
Overview

QCM-D vs SPR

Learn more about the differences between the two methods to find out which you should use.

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  • QSense
Overview

The Working Principles of QCM and QCM-D

Learn the fundamentals of how the technologies work, and what is the difference between them.

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  • QSense
Overview

What is Dissipation?

This is your chance to find out what it is, why it is important, and how it can be measured.

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  • QSense
Overview

Temperature Stability in QCM Measurements

Achieve reliable and reproducible QCM measurements by controlling the temperature.

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  • QSense
Guide

How to Generate Quality QCM-D Data

Follow our checklist for high-quality data and reproducible measurements.

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  • QSense
Overview

How QCM Results are Influenced by Layer Distribution

The distribution of the measured layer is key to your results. Discover why and how to handle it.

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  • QSense
Overview

What is Piezoelectricity?

Bone, wood and quartz are all piezoelectric materials. Learn about piezoelectricity and how it works

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  • QSense
Overview

QCM-D vs other QCMs

Let this brief overview guide you to your most suitable choice of QCM.

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  • QSense
Guide

How to Optimize the QCM-D Baseline Stability

9 steps to eliminate error sources and optimize reproducibility

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  • QSense
Overview

Characterization of Polymer-based Systems

Analyze layer build-up, conformation and molecular interaction with QSense QCM-D

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  • QSense
Case Study

QCM-D in Drug Formulation and Storage

Analyze and quantify protein adsorption to surfaces.

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  • QSense
Case Study

Analysis of Surfactant-Surface Interactions with QSense

Find out how to analyze surfactant interaction with surfaces at the nanoscale.

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  • QSense
Overview

What is a Viscoelastic material?

Ice, wood and a disks in the human spine are all viscoelastic materials. What does it really mean?

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  • QSense
Overview

Characterization of Biomolecular Interactions

Learn how biomolecular interactions can be analyzed using QSense® QCM-D technology and what information you can get.

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  • QSense
Webinar

Dfind Basic Training Course

Learn the basics of Dfind, get a walk-through of the software and watch two live demo examples.

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  • QSense
Webinar

Basics of QCM-D

Learn the fundamentals of the technology, its possibilities and limitations and get a deeper understanding of nanometer layers.

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  • QSense
Webinar

How do we Stop the Next Pandemic from an Unknown Virus?

Listen to the webinar from Prof Nam-Joon Cho on how his group work with preventing future pandemics.

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  • QSense
Webinar

Surface Science – a Field Rich in Science and Applications

Listen to Prof. Bengt Kasemo in this webinar on Surface Science - a field rich in science and applications.

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  • QSense
Overview

QCM-D Analysis in Virus-related Research

We collected examples of scientific publications in basic and applied research for you.

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  • QSense
Webinar

Biomaterials – Man-made Materials for Regenerative Medicine

Learn from Prof. Bengt Kasemo in this webinar on Biomaterials – man-made materials for regenerative medicine.

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  • QSense
Webinar

QCM-D as a Tool to Study the Binding of Viruses

Hear researcher Gustaf Rydell, on how they used QCM-D to study interactions between virus particles and membrane associated glycolipids.

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  • QSense
Webinar

QCM-D for Bacterial Adhesion Studies

Listen to Adam Olsson, McGill University, about how they use QCM-D for bacterial adhesion studies.

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  • QSense
Webinar

Nanocellulose Research with QCM-D

Watch our webinar on Nanocellulose Research with QCM-D where we will discuss thin films of cellulose nanofibrils development, and their characterization. 

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  • QSense
Webinar

Using QCM-D in the Food Industry

Learn more about QCM-D in food industry with studies of shelf life from Cornell University.

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  • QSense
Webinar

Characterization of Surfaces and Surface Reactions in Energy Storage

Learn how QCM-D can be used to characterize surfaces and reactions for energy storage from Dr. Archana Jaiswal, Nanoscience Instruments.

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  • QSense
Webinar

How Excipients, Surfaces and Formulation Conditions Affect Therapeutic Proteins

Can QCM-D quantify how surfactants affect protein-surface interaction? Watch this webinar with Dr. Archana Jaiswal to find out more.

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  • QSense
Overview

What is Biocompatibility?

In this overview we explain how biocompatibility is defined and give examples of what the property entails.

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  • QSense
Overview

The Dissipation Factor in QCM-D Technology

In this overview, we take a closer look at the behavior of the sensor oscillation at various types of loads and investigate what the D-factor reveals.

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  • QSense
Overview

Why it is Useful to use Multiple Overtones in QCM Measurements?

Learn what information the overtones offer in this overview.

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  • QSense
Overview

QSense Analysis in CMP

In this overview, we present how QSense® QCM-D technology can be used in molecule-surface interaction analysis and optimization of CMP related processes.

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  • QSense
Overview

Why the Resonance Frequency of a QCM Sensor is 5MHz

What determines the value of the fundamental resonance frequency? In this overview, we explain the theory behind the number.

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  • QSense
Case Study

Analyze Surface-induced Complement Activation

In this note we show how QCM-D can be used to evaluate biomaterial immunogenicity

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  • QSense
Case Study

Analyzing Vapor Uptake and Release with QCM-D

Read about how QCM-D can be used to analyse how water uptake and release affects film thickness

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  • QSense
Case Study

Monitoring of Polyelectrolyte Multilayer Build-up and Crosslinking using QCM-D

In this note we show how PEM build-up and crosslinking can be characterized with QCM-D

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  • QSense
Case Study

Screening Nanoparticle - Protein Interactions

Nanomaterials may interact with, and have adverse effects on, e.g., biological systems. Here we show how a model system can be used as an early screening method to characterize the nanoparticle uptake and biodurability

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  • QSense
Case Study

QCM-D as a Screening Tool for Protein Adsorption

Proteins tend to passively adsorb to surfaces via hydrophobic interactions. In this application note we show how protein adsorption can be characterized with QCM-D.

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  • QSense
Case Study

Characterization of Polymer Layer Swelling, Crosslinking and Collapse

Polymer brush response to ambient changes can be characterized with QCM-D. Here we show how

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  • QSense
Webinar

Adsorption and aggregation of monoclonal antibodies at silicone oil-water interfaces

Learn more about adsorption and aggregation of monoclonal antibodies at silicone oil-water interfaces with Ph.D. Aadithya Kannan at Genentech.

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