Chemical industry is an industrial sector serving a vast range of other industries ranging from personal care to agriculture and paint manufacturing to pharmaceuticals. Surface active agents are key components of any chemical formulation adsorbing at air-liquid, liquid-liquid and liquid-solid interfaces. Understanding the behavior of surfactant in formulations is important as surfactant optimization is one of the most important aspects of formulation development

Application areas

  • Effectiveness and efficiency of surfactants 
  • Stability of interfacial layers 
  • Surfactant adsorption and desorption from solid surfaces
  • Cleaning efficiency
  • Adsorption of biologics and excipients
  • Slurry additive and abrasive interaction
  • Polymer-surface interaction

Why choose Biolin Scientific?

With Biolin Scientific instruments you can study interactions of surfactants at air-liquid, liquid – liquid, and liquid-solid surfaces. You can determine the effectiveness and efficiency of surfactants or study the interfacial elasticity of adsorbed thin films with tensiometers. QCM-D (Quartz Crystal Microbalance with Dissipation monitoring) offers a tool to understand molecule-surface interaction dynamics, such as adsorption and desorption, at the nanoscale.

Using QSense to assess cleaning efficiency

Assess and optimize cleaning efficiency

Traditional cleaning analysis methods often lack time-resolved and mechanistic information which can impede the development of effective cleaning formulations and protocols. QSense® QCM-D (Quartz Crystal Microbalance with Dissipation monitoring) technology provides unique real-time data on interactions between cleaning agents, target soils, and surfaces, facilitating optimized product design and development.

 

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Determine surfactant effectiveness and efficiency

Surfactants lower surface tension by disrupting chemical bonds at the air-liquid or liquid-liquid interface. The effectiveness of a surfactant can be assessed through surface tension measurements, with lower values indicating greater effectiveness. Additionally, surfactant efficiency is crucial, as minimizing the amount used is important for both economic and environmental reasons. Measuring the critical micelle concentration provides a way to evaluate surfactant efficiency. 

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Surfactant stability

Surfactants stabilize air-liquid and liquid-liquid interfaces. The stability of these interfaces is meaningful in coatings and other formulations. Stability can be evaluated by studying the viscoelasticity of the interface through interfacial rheology measurements. 

Analyze surfactant adsorption with QSense QCM-D

Characterize surfactant-surface interaction

Surfactants are key components in many products and processes, where performance often depends on how they interact with surfaces over time. QCM-D enables time-resolved analysis of these interactions at the nanoscale, helping you build fundamental understanding and apply those insights throughout product development and optimization.

QSense QCM sensors for Biopharma

Analyze adsorption of biologics and excipients

The stability and performance of complex formulations can be influenced by how biologics, excipients and other components adsorb to material surfaces. QSense QCM-D helps you analyze these surface interactions in real time at the nanoscale, supporting material selection, compatibility assessment and formulation optimization.

Analysis of polymer systems

Characterize polymer-based systems

Polymer-based systems are used across many applications to tailor interfacial properties and promote functions such as biocompatibility, antifouling performance and drug delivery. QCM-D analysis enables real-time monitoring of polymer–surface interactions, layer build-up and transitions between hydrated and dehydrated states, helping you understand and optimize polymer behavior at interfaces.

QSense in post CMP cleaning

Optimize the chemical part of the CMP process

CMP performance depends on how slurry additives and abrasive particles interact with surfaces at the nanoscale. QSense® QCM-D enables real-time analysis of these interactions and residue removal, helping you optimize slurry chemistry and surface cleanliness.

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