QCM-D

QSense Core One

Name: QSense Explorer
Brand: Biolin Scientific
Availability: InStock

The premium manual QCM-D instrument for complete experimental control and effortless versatility.

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See how Core One combines premium QCM-D data quality, hands-on control and broad configuration flexibility in one compact manual platform.

Proven in published research

Explore 20 000+ publications featuring instruments from the QSense, Attension and KSV NIMA portfolio, across a wide range of research areas and applications.

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Adsorption of Tannic Acid onto Gold Surfaces

Thin film coatings are widely applicable in materials ...

Moisture-induced electrical power generation with waste activated sludge

Moisture-induced power generation from pure bacterial ...

Silicon Nitride Selective Functionalization with Aqueous Cellulose

In semiconductor device manufacturing, it is often ...

Comprehensive characterization of gas diffusion through graphene oxide membranes

Graphene oxide (GO) based multi-layered membranes have ...

Adsorption and Lubrication of Glutamic Acid-Based Surfactant with Calcium Ions

The adsorption and lubrication of an amino acid-based ...

Study of SARS-CoV-2 Spike Protein Wild-Type and the Variants of Concern Real-Time Interactions with Monoclonal Antibodies and Convalescent Human Serum

The spike (S) protein and its receptor-binding domain ...

Assembly of zein/propylene glycol alginate nanoparticles in aqueous ethanol and the binding kinetics

The interaction between zein and propylene glycol ...

Environmentally stable and stretchable polymer electronics enabled by surface-tethered nanostructured molecular-level protection

Stretchable polymer semiconductors (PSCs) are essential ...

Synergy Effect between Sodium Oleate and Alcohol Ethoxylates on the Reverse Flotation of Quartz

In this study, an optimized method was presented for ...

Lubrication mechanism of a strong tribofilm by imidazolium ionic liquid

Friction modifiers (FMs) are surface-active additives ...

Interfacial adsorption behavior of the Aspergillus oryzae lipase-chitosan complex and stability evaluation of the resultant Pickering emulsion

To prompt the application of the chitosan ...

Temperature and concentration dependence of the electrochemical PtHg4 alloy formation for mercury decontamination

New and improved methods to remove toxic mercury from ...

Phenomena

Adsorption
Desorption
Binding and interactions
Swelling
De-swelling, crosslinking and collapse
Degradation, corrosion and etching

Premium data quality with complete experimental freedom

0.01 Hz noise floor

Detect tiny interactions and films

Key features

Sharper signals for stronger insights

Low noise, enhanced stability and improved signal-to-noise performance help resolve subtle and low-mass changes.
Seven measured harmonics

Gain richer information across the full harmonic range and support viscoelastic modelling of soft films.
Smart pre-run quality checks

Verify resonance, temperature, drift and baseline stability before using valuable time and sample.
Flexible, adaptive sampling

Select exact measurement intervals and adjust them during a running experiment.
Common time-zero across instruments

Synchronize QSense Core One with external analytical instruments. A trigger function provides a common time-zero, simplifying data synchronization and post-processing.
Compact laboratory footprint

Gain updated QSense performance and broad configuration flexibility in a smaller instrument format.

Complete analysis set-up

QSOFT AND DFIND SOFTWARE

QSense software is tailored to help you maximize the potential of your QCM-D measurements. With QSoft capturing your data and Dfind simplifying your analysis, you can streamline your research process effortlessly.

Measurement conditions

Flow mode
Stagnant mode
Gas phase Requires add-on
Liquid phase
Harsh chemicals
Low temperature Requires add-on
High temperature Requires add-on
Humidity Requires add-on
Variable pressure Requires customization
Inert surface Requires add-on

Article

QCM-D Measurement

Exploring Lipid-Based Systems with QSense QCM-D analysis

Knowledge

QCM-D Measurement

Overview

Temperature stability in QCM-measuremements

A closer look

QSense Core One combines trusted QSense measurement technology with next-generation electronics, advanced signal processing and intuitive software. It gives scientists the data quality, control and flexibility needed to design experiments around their scientific questions.

Why to choose Core One ?

Reveal small and fast interfacial changes

Sharper data

Core One combines low noise and drift with improved signal-to-noise performance, broadening the usable sensitivity range in liquid measurements.

Reliable measurements from the first run

Smarter setup

Automatic resonance tracking and built-in checks help identify unstable conditions before the experiment begins.

One platform for different questions

More possibilities

Use interchangeable chambers, add-on modules and complementary analytical techniques without moving to a different instrument platform.

Sharper signals for stronger insights

QSense Core One brings premium QCM-D data quality to manual, tubing-based experiments. Next-generation electronics, advanced signal processing and trusted QSense measurement technology deliver cleaner signals, lower noise and enhanced stability.

Whether you are studying low-mass adsorption, long-term kinetics or complex viscoelastic films, Core One helps reveal subtle interfacial processes with clarity and confidence.

Can detect adsorption events down to 0,5 ng/cm²
0.6 Hz/h drift
0.01 Hz frequency noise

Smarter workflow with QSoft

QSoft has been redesigned to make manual QCM-D experiments easier to configure, verify and monitor. Automatic resonance tracking, pre-run checks and flexible acquisition settings guide the user toward high-quality measurements without removing experimental control.

automatic resonance tracking;
signal quality evaluation;
stability thresholds;
exact acquisition intervals;
live adjustment during the run;
automatic timestamps.

Build the experimental setup your research requires

QSense Core One supports QCM-D experiments beyond a standard flow configuration. Connect complementary analytical instruments, synchronize data streams and move between compatible modules for electrochemistry, microscopy, ellipsometry, humidity, elevated temperature and specialized surface access.

Instrument Selector

Our Instrument Selector will guide you along the way to your new instrument. Answer a few questions and the tool will provide you with the top choices based on your specific needs.

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What QSense Core One detects

Detect smaller surface changes

Improved sensitivity helps reveal subtle mass changes - from low molecular weight binding and partial surface coverage to very thin, rigid films.

Reliable long-term measurements

Low drift enables confident monitoring of slow adsorption processes and small signals that require extended measurement times.

Better data for viscoelastic modelling

Lower noise provides clearer, more resolved harmonics - even at higher overtones - improving the quality of data available for viscoelastic modelling.

Measurement Range and Capacity

Measurement channels	1
Working temperature	15 to 65 °C, 4 to 150 °C using add-on chamber (QSense High Temperature chamber)
Sensors (frequency range)	5 MHz (1-72)
Number of measured harmonics	7, allows for full viscoelastic modeling

Sample and Fluidics

Minimum sample volume, stagnant mode	~ 40 μl ~ 10 μl using add-on module (QSense Open module)
Minimum sample volume, flow mode	~ 200 μl
Flow rates	25-150 μl/min applicable for QSense setup (Peristaltic pump settable to 0-1 ml/min)

Performance Characteristics

Maximum time resolution	100 data points per second (each data point represents an f and D value)
Minimum noise^a	Frequency noise : 0.01 Hz Mass : 0.16 ng/cm² Dissipation noise : 11 x 10^-9
Long-term stability	Frequency: < 0,6 Hz/h Dissipation: < 0.1 x 10^-6 /h Temperature: < 0.5 ˚C/h

Dimensions and Weight

Electronics unit-dimensions (cm)	18/36/21
Electronics unit-weight(kg)	9
Measurement chamber-dimensions(cm)	5/10/15
Measurement chamber-weight(kg)	1

Software-QSoft Acquisition

Data output	Time resolved Frequency and Dissipation for 7 harmonics
Computer requirements	USB 2.0
Operating system	Windows 11(earlier Windows versions may not fully work and support cannot be guaranteed)
Import/export	Excel, BMP, JPG, WMF, GIF, PCX, PNG, TXT

Software-Dfind Analysis

Data output	Thickness (or mass), viscosity, shear modulus and the frequency dependence of the viscosity and shear modulus. Kinetics, slope, rise time and more
Computer requirements	PC with 64-bit > 1366×768 px screen resolution, > 4 GB RAM
Operating system	Windows 11(earlier Windows versions may not fully work and support cannot be guaranteed)
Import/export	CSV files. Decimal separator, full stop or comma

Electrical

Power supply and frequency

100 / 115-120 / 220 / 230-240 V AC, 50-60 Hz
The power supply should be properly grounded

Standard sensors

The sensor is at the heart of the QCM-D experiment. Browse the widest range of sensors on the market to find out which sensor material and coating is best suited for your research.

We offer over 50 standard sensors - from various metals, oxides and carbides to polymers, functionalized coatings and and standardized soils. Our sensors are developed and produced to provide you with stable, reliable and reproducible data. Full performance is ensured through extensive quality controls and guaranteed for one-time use according to the recommendations.

Customized sensors

Sensor materials and coatings based on your specific needs

Top suggestions

Stainless Steel SS2343

QSX 305

PS-Hydrophobic Polystyrene

See more here

Intuitive QSoft software

QSoft has been redesigned to make QCM-D experiments easier to set up, monitor, and optimize. Intuitive workflows, automatic resonance tracking, and built-in quality checks help secure reliable measurements from the first run, while flexible data acquisition and third-party instrument connectivity provide the control needed for advanced research. Spend less time troubleshooting and more time generating meaningful results.

Key features

Easy experimental set-up

User friendly interface with guided workflows, lets you to define chamber, set temperature, and stability criteria in few simple steps.
Extensive quality control

QSoft verifies resonance, temperature and baseline stability across all seven harmonics, then continuously monitors signal quality for reliable data.
Live results tracking

Track frequency and dissipation in real time across all harmonics. Set and adjust the data collection interval during the measurement to achieve the time resolution needed for different stages of your experiment.

Data Analysis with Dfind software

QSense Dfind helps you complete the journey from measurement to understanding. Designed specifically for QCM-D analysis, Dfind streamlines the entire workflow from raw data review and modelling to information extraction and final reporting.

Key features

Batch mode analysis

Dfind can process multiple data sets at the same time. Irrespective of whether you need to analyze one data set or 100, Dfind will crunch the data in one go and present you the results in a few seconds
Ready to use templates

The data analysis is executed using ‘templates’. This means that you only need to setup a specific analysis sequence once and then it can be re-used over and over on different data sets.
The modelling of data

Once you have uploaded raw data and entered the density of the film, the software will provide the modelling results for you.

Would you like to know more about the details of Dfind and learn how the subscription works?

Add more possibilities

QSense Core One has a removable flow module that can be exchanged to to fit your research needs. We have selected a few extras for you to widen your possibilities, and you can find more choices below.

Electrochemistry Module

For simultaneous QCM-D and electrochemistry measurements on the same surface. Enables cyclic voltammetry and electrochemical impedance measurements to explore polymer behavior, electrostatic interactions, corrosion, etc.

Ellipsometry Module

Enables simultaneous QCM-D and ellipsometry measurements on the same surface, which allows for quantification of solvent content in the film. It also gives a refined analysis of the morphological changes of the adsorbed film.

Window Module

The Window Module allows optical access to the sensor surface through a sapphire window. It enables experiments with UV-induced reactions and when used in the QSense Core One chamber, the compact design also enables microscopy studies of reactions on the sensor.

High Temperature Chamber

With the High Temperature Chamber you can perform measurements in an extended temperature range of 4-150°C.

Configure QSense Core One with accessories & modules in our Instrument Selector!

What others say

Our instruments are present at many prestigious universities and research facilities worldwide. Take a minute to find out what others say about QSense.

citat8

Sivashankar Krishnamoorthy on QSense

"We use the QSense Explorer and Analyzer systems. We could get started rather quickly, thanks to the ease of using the systems."

Dr Sivashankar Krishnamoorthy, Luxembourg Institute of Science and Technology

"We spent time to understand different ways to customize the sensor chips, assay configuration, and flow routines to rational design of nanoplasmonic and nanopatterned sensors. Have had a great experience so far."

citat8

Marité Cárdenas on QSense

"QSense instruments are a great tool for our biophysical research. They enable rapid screening for biomolecular interaction at lipid bilayers and also allow optimizing the parameters for deposition of thin films."

Professor Dr. Marité Cárdenas, Health and Society, Malmö University

"The instrument is easy to use, and has a long working life as long as you follow the maintenance instructions! The technical staff at Biolin Scientific are a pleasure to work with: They are nice and always give quick feedback and support."

citat8

Kenichi Sakai on QSense

"We regard QCM-D as a valuable measuring tool due to its high sensitivity and stability and find it applicable for versatile studies because of its availabilities of sensors with different types of surfaces. In this context I would say QCM-D is the best suitable solution for simulating a variety of nanoscale interaction behaviors both real-time & in-situ."

Kenichi Sakai, Associate Professor, Tokyo University of Science

"We are working on academic research in the field of colloid and interface chemistry and our main work is synthesis of novel surfactants and characterization of their properties. We use QCM-D as a must-tool to comprehend molecular adsorption/desorption behaviors specifically observed at a solid-liquid interface."

citat8

Jodie Lutkenhaus on QSense

"We can monitor the mass change of our system in real-time. I can tell you that for every electron moved, this amount of mass changed. That’s powerful. You can’t really get that with any other system."

Jodie Lutkenhaus, Associate Professor, Texas A&M University

"We use the QSense high temperature model that allows us to investigate polyelectrolyte complexes and their response to temperature. We’re also using the electrochemistry module so we can run our standard electrochemical measurements at the same time as we run the QCM-D."

citat8

Malkiat Johal on QSense

"I have found QSense to be one of the best techniques for an undergraduate lab because it’s turnkey and it requires very little maintenance."

Malkiat Johal, Professor of Chemistry, Pomona College

"The operating principles are straightforward and the students can focus on the science. And so, that’s something that we have been really happy with, it really works in this kind of setting. It’s an ideal method for an undergraduate surface science lab."

Learn more

We have gathered all our in-depth knowledge associated with QSense Core One. Browse around amongst guides, overviews, and white papers to find a topic of interest.

QSense

Webinar

How Excipients, Surfaces and Formulation Conditions Affect Therapeutic Proteins

Can QCM-D quantify how surfactants affect protein-surface interaction? Watch this webinar with Dr. Archana Jaiswal to find out more.

Go there

QSense

Webinar

Basics of QCM-D

Learn the fundamentals of the technology, its possibilities and limitations and get a deeper understanding of nanometer layers.

Go there

QSense

Guide

How to Optimize the QCM-D Baseline Stability

9 steps to eliminate error sources and optimize reproducibility

Download

QSense

Overview

The Working Principles of QCM and QCM-D

Learn the fundamentals of how the technologies work, and what is the difference between them.

Biolin Scientific China

German Webshop

In a hurry?

Proven in published research

Phenomena

Key features

Sharper signals for stronger insights

Seven measured harmonics

Smart pre-run quality checks

Flexible, adaptive sampling

Common time-zero across instruments

Compact laboratory footprint

Measurement conditions

QCM-D Measurement

QCM-D Measurement

Temperature stability in QCM-measuremements

A closer look

Sharper data

Smarter setup

More possibilities

Instrument Selector

Measurement Range and Capacity

Sample and Fluidics

Performance Characteristics

Dimensions and Weight

Software-QSoft Acquisition

Software-Dfind Analysis

Electrical

Top suggestions

See more here

Intuitive QSoft software

Key features

Easy experimental set-up

Extensive quality control

Live results tracking

Data Analysis with Dfind software

Key features

Batch mode analysis

Ready to use templates

The modelling of data

Add more possibilities

Electrochemistry Module

Ellipsometry Module

Window Module

High Temperature Chamber

What others say

Sivashankar Krishnamoorthy on QSense

Dr Sivashankar Krishnamoorthy, Luxembourg Institute of Science and Technology

Marité Cárdenas on QSense

Professor Dr. Marité Cárdenas, Health and Society, Malmö University

Kenichi Sakai on QSense

Kenichi Sakai, Associate Professor, Tokyo University of Science

Jodie Lutkenhaus on QSense

Jodie Lutkenhaus, Associate Professor, Texas A&M University

Malkiat Johal on QSense

Malkiat Johal, Professor of Chemistry, Pomona College

Learn more

How Excipients, Surfaces and Formulation Conditions Affect Therapeutic Proteins

Basics of QCM-D

How to Optimize the QCM-D Baseline Stability

The Working Principles of QCM and QCM-D

QCM-D in Drug Formulation and Storage

QCM-D vs SPR

QCM-D vs other QCMs

What is Piezoelectricity?

How QCM Results are Influenced by Layer Distribution

Why the Resonance Frequency of a QCM Sensor is 5MHz

Characterization of Polymer-based Systems

Using QCM-D in the Food Industry

What is Biocompatibility?

Why it is Useful to use Multiple Overtones in QCM Measurements?

Nanocellulose Research with QCM-D

Analysis of Surfactant-Surface Interactions with QSense

Getting Started with QSense Dfind

Data Modeling in QSense Dfind

QCM-D as a Screening Tool for Protein Adsorption

Analyzing Vapor Uptake and Release with QCM-D

Surface Science – a Field Rich in Science and Applications

QCM-D Data Analysis

QSense Explorer Online Demo