Biointerface science is foundational to advancements in areas that impact our health, technology, and environment. The behavior at the boundary between biological systems and materials determines the performance and safety of medical devices, diagnostics, materials, and sensors. Mastering these interfaces is key to innovation and better outcomes across many fields.
Biointerfaces—phenomena where biological molecules interact with materials—occur in a wide range of contexts, from medicine and biotechnology to environmental and industrial settings. This breadth makes it essential to study and understand these interfaces for advancement and innovation across many fields. For over two decades, QSense® QCM-D has been a cornerstone of the discipline, enabling real-time, label-free analysis of biomolecular and material interactions at surfaces and interfaces. By providing key insights into the mechanisms at play, this versatile technology deepens fundamental understanding and supports the rational design of biomaterials, medical devices, sensors, drug delivery systems, and more—driving progress from basic discovery to advanced applications.
Track the dynamics of adsorption, desorption, layer build-up, and degradation to reveal mechanisms that drive material performance in biological environments.
Assess the performance and stability of antifouling, bioactive, or functional coatings under relevant conditions to ensure optimal and sustained surface properties.
Identify and quantify phenomena such as non-specific adsorption, biofilm formation, and surface fouling that may compromise material performance, enabling proactive optimization of materials and coatings.

Download the overview to read about some of the latest and most cutting-edge uses of QCM-D technology in biointerface science, demonstrating the breadth and depth of scientific insights that are possible to obtain with QSense QCM-D.
QSense is an advanced, surface-sensitive technology that enables real-time, label-free analysis of molecule–surface interactions and reactions. It is used to investigate phenomena such as adsorption, desorption, and structural or mechanical changes in surface-adhering layers.
Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) is a real-time, surface sensitive technique for analyzing surface-interaction phenomena, thin film formation and layer properties.
Easy to implement in any laboratory setting
Real-time monitoring of molecular interactions and reactions at surfaces and interfaces for insights into interfacial processes and mechanisms
Obtain robust results from small sample volumes, down to 90 μl
Insights delivered within hours
Ensure rapid and reproducible measurements
Investigate molecular interactions with diverse material surfaces
QSense Omni is the latest QSense instrument, giving you the sharpest QCM-D data and a smooth journey in the lab.
PDMS is an excellent choice for
lubrication of syringes and similar lab wares, where maintaining the integrity of stored fluids and biological samples is crucial. Additionally, its thermal and electrical insulation properties protect sensitive samples and components.
The sensor is at the heart of the QCM-D experiment. Browse the widest range of sensors on the market to find out which sensor material and coating is best suited for your research needs.
QSense sensors for biointerface interaction analysis offer a versatile selection of QCM-D sensors designed to replicate surface materials commonly used in this field.
Thousands of studies, countless discoveries—here are a few examples
Self-assembly of short biopeptides onto skin tissue components studied using QCM-D
Screening of the binding affinity of serum proteins to lipid nanoparticles in a cell free environment
Protein Adsorption and Layer Formation at the Stainless Steel-Solution Interface Mediates Shear-Induced Particle Formation for an IgG1 Monoclonal Antibody
Synergy between endo/exo-glucanases and expansin enhances enzyme adsorption and cellulose conversion
Supported lipid bilayer platform for characterizing the membrane-disruptive behaviors of Triton X-100 and potential detergent replacements
QCM-D Study of Time-Resolved Cell Adhesion and Detachment: Effect of Surface Free Energy on Eukaryotes and Prokaryotes