In the dynamic lifecycle of a biopharmaceutical drug, from inception to patient use,
stability and material compatibility is crucial. The complex interactions with various surfaces can lead to challenges such as unexpected adsorption, concentration depletion, or the formation of proteinaceous particles.
Detecting these potential issues early on is essential, as late discovery could disrupt project timelines and result in substantial financial setbacks. Proactive screening for potential surface-induced instabilities during development becomes vital to mitigate risks. This approach enables a smoother development, reducing risk of later failure, for example during final storage testing.
Our solution - QSense® QCM-D technology helps you to analyze biopharmaceutical interactions comprehensively. This surface-sensitive method offers insights into molecular adsorption, desorption, and structural rearrangements at the nanoscale, facilitating rapid detection of potential incompatibilities and providing a mechanistic understanding of solid-liquid interface processes.
Utilize QCM-D for assessments of manufacturing, storage, and administration materials, providing real-time data on antibody and excipient adsorption. This proactive approach not only enhances your understanding of surfactant mechanisms but also helps to detect potential incompatibilities early by measuring adsorbed quantities, ensuring efficient risk mitigation.
Download the white paper to learn more about how QSense analysis can be used to reduce the risk of late discovery of incompatibilities!
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