QCM-D: Dissipation Monitoring Enables Accurate Analysis of Soft Materials

Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) is the measurement principle for the Q-Sense instruments. The QCM-D technology is a real-time surface sensitive technique to monitor and characterize thin films on a surface in terms of adsorption, desorption, molecular interactions and structural properties. With the QCM-D technology, two parameters—frequency (related to mass/thickness) and dissipation (related to rigidity)—are monitored simultaneously, in real-time, as molecular layers form on the sensor surface.

 

  1. Binding of a small globular molecule
    • Moderate frequency change ∆ƒ (mass change). 
    • Low dissipation change, ∆D (indicating rigid film).
  2. Binding of a large elongated molecule
    • Large ∆ƒ (more mass).
    • Large ∆D (soft film).
  3. Rinsing with regenerating buffer removing elongated molecule
    • ƒ back to phase 1 (mass removal).
    • D back to phase 1 (back to rigid film).

 

 
QCM-D Technology