What is QCM?
Malin Edvardsson Nov 3, ’22 3 min

What is QCM?

Quartz Crystal Microbalance, QCM, is a surface sensitive real-time technology that can be used to monitor molecular interaction at surfaces and interfaces via detection of changes in the resonance frequency of the QCM sensor. Using the Sauerbrey equation, the frequency change can be converted to change in mass, allowing characterization of mass uptake and mass loss at the surface.

From thin-film deposition in vacuum and gas phase to liquid phase applications

QCM technology, which is essentially a balance for very small masses, has been around since the 60’s. With a mass resolution typically in the ng/cm2 range, it enables monitoring of build-up and removal of thin and rigid layers at the sensor surface. Traditionally, it was used for monitoring of thin-film deposition in vacuum and gas phase, but the last couple of decades the traditional QCM configuration has evolved and extended versions, such as QCM-D, now exist. This has enabled the usage of the technology to expand and spread into other applications, and the method is now commonly used for liquid-phase measurements.

Piezoelectricity and the QCM working principle - relating frequency change to mas change

The core of QCM technology is the sensor, which is traditionally made of quartz, a piezoelectric material. A thin disk of the piezoelectric material is sandwiched between two electrodes, Fig 1A. Applying an electric field over the disk, there will be a resulting mechanical oscillation, Fig 1B. The resonance frequency depends on the sensor design, and is typically 5-10MHz, but it can be both lower and higher.

QCM working principle sensor oscillation2

Figure 1. Schematic illustration (not to scale) of a (A) QCM sensor made of a thin disk of a piezoelectric material sandwiched between two electrodes. The disk material is typically quartz, and the electrodes are typically made of gold, but other materials can be used. In (B), an alternating voltage is applied over the sensor, inducing a mechanical oscillation of the sensor

The QCM measurement is achieved by monitoring the change in resonance frequency, Δf, when mass is added to, or removed from, the sensor surface. When mass is added, the resonance frequency decreases, Fig. 2 and vice versa.

QCM quartz crystal microbalanceFigure 2. QCM technology collects time-resolved information on frequency changes of the QCM sensor and can detect mass uptake at the sensor surface. The schematic illustration shows (I) a bare sensor surface and stable baseline of Δf. In step (II), molecules adsorb to the sensor surface which results in a frequency decrease. In (III), the surface uptake has been completed and the frequency response has stabilized. The frequency shift between I and III can be used to quantify the mass uptake at the sensor surface.


By following the changes in Δf, molecule – surface interaction can be detected and mass uptake and release from the surface can be quantified, Fig 3.

QCM schematic mass uptake and removalFigure 3. Schematic illustration of molecules (left) adsorbing to and (right) desorbing from the QCM sensor surface. The bottom panels illustrate the resulting changes in quantified mass, i.e., mass uptake as molecules adsorb and mass loss as they leave the surface.

Concluding remarks

In summary, QCM technology is a real-time, surface sensitive technique that monitors the change in mass or thickness of layers adhering to the surface of the QCM sensor. This is achieved by measuring the change in resonance frequency of the quartz crystal upon excitation by a driving voltage.

Download the overview to learn more about QCM technology and how it works.

What is QCM

Download the overview to learn more about QCM technology

Overview  Working principles of QCM and QCM-D technology  Download

Editor’s note: This post was originally published in January 2018 and has been updated for comprehensiveness

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