The effect of Surface roughness and wettability on biocompatibility of biomaterials and Medical devices.
The good lubricity is needed as the poorly lubricated catheters can cause trauma as a result of high frictional forces between the biomaterial and tissue.
To better describe the real surfaces, different wetting states have been proposed. The most discussed are Wenzel state and Cassie-Baxter state.
Interactions at the material surface is influenced by the wettability of the material. Wettability measurements are done to evaluate biocompatibility.
Cell-biomaterial interactions are affected by the surface properties of the material such as surface chemistry, wettability and surface roughness.
While contact angle goniometry has been around for many years, we have recently developed a way to account for the underlying surface’s micro-scale roughness.