Proteins are vital for life and perform a wide range of essential biochemical tasks in all living organisms. Cells of these organisms are hence under a constant pressure to maintain an optimal protein environment, assuring all proteins are correctly folded and functional.
Unfolded proteins are sticky and tend to form so-called protein aggregates with either themselves, other proteins or when binding to exposed surfaces within the cell. Aggregation mechanisms depend on both primary amino acid sequence of the protein and external environment such as pH, salt and temperature. Most protein aggregates can be reversed or degraded by the cell protein quality system (molecular chaperones or proteases).
However, sometimes the control mechanisms fail and accumulated aggregates transform into amyloid plaques and other protein megastructures. This is the case in protein misfolding diseases, proteopathies, such as Alzheimer’s and Parkinson’s disease. Amyloids behave very differently to functional soluble protein, for example in regards to rigidity. Current trends within this field of research is to study the kinetic buildup of such megastructures and consequently also searching for therapeutic agents that prevent buildup and hence disease. Protein misfolding diseases are a huge threat to the increasing ageing population, with such diseases affecting more than 10% of all people over the age of 65.
Learn about how aggregation of protein Tau in tauopathies, a sub-set of neurodegenerative diseases, can be studied with QCM-D.
Learn about lipid nanoparticle designs for drug delivery purposes and related research
Read about the key signatures in the QCM data that reveal if viscoelastic modelling should be used to extract the mass.
Viscoelasticity is a quality involving both viscous and elastic properties at the same time.
Read about what the different QCM parameters mean and which ones you should keep an eye on
QCM-sensor regeneration can be a resource efficient way of running experiments. Learn about aspects to consider if you plan to resuse ypur sensors.
Read about how QSense QCM-D analysis was used to better understand why and what affects an increased transmissibility of SARS-CoV-2
Listen to the webinar to learn more about how to combine QCM-D and Neutron reflectrometry to examine membrane biochemistry at the solid-liquid Interface
Learn about what aspects to consider when preparing your QCM samples and solvents
Read about how QSense QCM-D was used in the development of a new thermoresponsive polymer brush with antifouling properties for biomedical applications.
Learn more about recent efforts on implementing QCM-D and EQCM-D for reliable biosensing