Since the beginning of this century, QSense QCM-D has been used to study viruses and virus-interaction with their immediate surrounding. Here we give examples of virus-related research where QCM-D technology has been used.
QCM-D, which is a surface-sensitive technology, has been used to explore and characterize various aspects of biological systems for more than two decades.1-3 The time-resolved information of mass change at the surface can be used to study biomolecular interactions such as surface-protein, lipid-protein and protein-protein interactions, Fig. 1, and reveal, for example, interaction patterns as a function of molecules, surface and solvent conditions.
An area where such information is useful is in virus-related research. In this field, QCM-D technology has been used to shed light on several different aspects of virus behavior and interaction with the surrounding. Over the years, a vast range of viruses have been studied, for example Norovirus, Poxvirus, Rotavirus, Herpesvirus, Ebola, Hepatitis C and Zika virus.
Figure 1. Schematic illustration of how the QCM-D response can be used to reveal biomolecular interactions such as (top panel) (A) adsorption, (B) binding and (C) enzymatic action. The Δf and ΔD data (bottom panel) reflect time-resolved mass uptake and layer softness respectively and can also be used to quantify the layer thickness.
QCM-D analysis is used in both basic and applied research. The aim could for example be to gain increased knowledge and to get a fundamental understanding of virus behavior and interaction patterns in a certain context. In more applied work, the aim could for example be to develop antiviral therapies.
In the overview below, we have compiled a list of examples of virus-related publications where QCM-D technology has been used. Download the overview to learn more
Read about how protein adsorption at various surface and solution conditions quickly can be measured
Read about what single-harmonic and multi-harmonic QCM-D means and what the difference is between these instruments.
Read about how QSense QCM-D analysis is used as a powerful tool to investigate protein-lipid nanoparticles binding affinity
Learn about the difference between the theoretical QCM sensitivity and the sensitivity which is relevant in a measurement situation.
Read about the piezoelectric effect and how piezoelectricity arises
Learn more about QSense 4th generation QCM-D platform which provides a sharper tool in the scientist toolbox and simplifies data interpretation.
Learn about how biointerfaces and biomolecular interactions can be studied using QSense® QCM-D and what information these measurements offer.
Read about Prof. Jackman's experience using QCM-D to study surfactant-interaction with model membranes
Sign upp for the webinar to learn more about how QCM-D is used to study biomaterial-induced activation of the immune system