Thanks to the treatment efficiency for various diseases, biologics, such as therapeutic monoclonal antibodies, are on a steady rise and are expected to continue to grow in popularity. Although holding great potential in terms of health gains, there are challenges associated with drug development using these relatively large and complex molecules. One challenge is that of surface interaction. Throughout their lifespan, from manufacturing to storage and administration, the therapeutic drug will interact with many different surfaces which may result in adsorption, loss of concentration and/or formation of proteinaceous particles. Late discovery of incompatibilities may pose a risk to product development timelines and be very expensive. Screening for surface-induced instabilities already during development could help reduce the risk of such events and mitigate potential challenges before they lead to program delays and unplanned costs.
QSense QCM-D is a robust and reproducible analysis method that can detect the interaction between biopharmaceuticals and materials relevant for manufacturing, storage, and administration. An assessment of the surface interaction of antibodies and excipients can provide insight into when and why incompatibilities could occur and it can also help identify ways to mitigate to reduce the risk of later failure.
Join our webinar to learn more about QSense QCM-D technology and how it can be used to analyze the adsorption of biologics and excipients to materials used in manufacturing, storage, and administration of biopharmaceuticals. In this webinar, I will introduce you to QSense solution and guide you through two case examples showing how the method can be used to assess biopharmaceutical interaction in the context of pre-filled syringes. As a proof of concept, we demonstrate the capabilities of the technology to measure antibody adsorption to different materials and the effect of added surfactant. The case examples are then followed by a brief demonstration of the QSense Omni instrument and how a QCM-D measurement is run in practice.
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Explore the key factors influencing QCM baseline stability and get advice on management strategies
Learn more about how dissipation can be measured in QCM:s and the pros and cons of the different methods.
Read about how QSense QCM-D was used to study antibody fouling on steel surfaces.
Read about what determines the sensing depth of the QCM-D technology and get examples of typical values
Read the guidelines on how to decide which QCM instrument will be the most suitable for your needs
Read about how protein adsorption at various surface and solution conditions quickly can be measured
Read about what single-harmonic and multi-harmonic QCM-D means and what the difference is between these instruments.
Read about how QSense QCM-D analysis is used as a powerful tool to investigate protein-lipid nanoparticles binding affinity
Learn about the difference between the theoretical QCM sensitivity and the sensitivity which is relevant in a measurement situation.
Erik is a Senior Application Scientist at Biolin Scientific. He has a broad scientific background from research projects and innovation management. Erik is particularly interested in surface science and has a Ph.D. in bioscience from 2013 where he developed biosensing applications focusing on QCM-D.