Assess stability and material compatibility of biopharmaceutical formulations with QCM-D
Erik Nilebäck Apr 23, ’24 ~ 2 min

Assess stability and material compatibility of biopharmaceutical formulations with QCM-D

Thanks to the treatment efficiency for various diseases, biologics, such as therapeutic monoclonal antibodies, are on a steady rise and are expected to continue to grow in popularity. Although holding great potential in terms of health gains, there are challenges associated with drug development using these relatively large and complex molecules. One challenge is that of surface interaction. Throughout their lifespan, from manufacturing to storage and administration, the therapeutic drug will interact with many different surfaces which may result in adsorption, loss of concentration and/or formation of proteinaceous particles. Late discovery of incompatibilities may pose a risk to product development timelines and be very expensive. Screening for surface-induced instabilities already during development could help reduce the risk of such events and mitigate potential challenges before they lead to program delays and unplanned costs.

Use surface-based analysis to get insight into biopharmaceutical–material interaction

QSense QCM-D is a robust and reproducible analysis method that can detect the interaction between biopharmaceuticals and materials relevant for manufacturing, storage, and administration. An assessment of the surface interaction of antibodies and excipients can provide insight into when and why incompatibilities could occur and it can also help identify ways to mitigate to reduce the risk of later failure.

Get an early indication of potential incompatibilities and identify ways to mitigate

Join our webinar to learn more about QSense QCM-D technology and how it can be used to analyze the adsorption of biologics and excipients to materials used in manufacturing, storage, and administration of biopharmaceuticals. In this webinar, I will introduce you to QSense solution and guide you through two case examples showing how the method can be used to assess biopharmaceutical interaction in the context of pre-filled syringes. As a proof of concept, we demonstrate the capabilities of the technology to measure antibody adsorption to different materials and the effect of added surfactant. The case examples are then followed by a brief demonstration of the QSense Omni instrument and how a QCM-D measurement is run in practice.

Pharmaceutical container closure materials-1

Learn more about how QSense QCM-D is used to assess stability and material compatibility of biopharmaceuticals

Register for the webinar

Explore the blog

You have only scratched the surface.



View all