The general description of QCM-D technology is that it is a balance for very small masses. And indeed, it is, but the information that you can extract from the data is so much more than just mass.
The QCM-D offers a lot more than just the mass
The collected parameters f and D, and particularly at multiple harmonics, allow for the quantification of both mass and thickness as well as viscoelastic properties of the layer at the surface. Add to this, the fact that the information is time-resolved. This means that not only can you characterize the final formed layer, but you can also follow the dynamic evolution of the surface interactions and get an understanding of how these happen and why. The measured parameters can also provide information on the level of hydration, and changes thereof, such as film swelling or film collapse.
Characterize surface interactions and layer properties
The possibility to follow dynamic processes such as film formation, film degradation, and structural rearrangements enables the exploration as well as characterization and optimization of nanoscale systems including for example biomolecules, polymers, surfactants and nanoparticles.
Download the overview to read more about what information you can extract from QCM-D analysis.
Recent research results could help designing formulations better stabilized against protein aggregation, one of the main challenges in pharmaceutical development. QSense QCM-D analysis helped piecing the puzzle together